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This has been attributed to their developmental sequence, where bones further from the head develop later and are more impacted by fluctuating growth conditions. We aimed to explore limb dimensions within this framework, known as the laws of developmental direction, in children (0.09\u201311.75\u2009years) from a documented skeletal collection of low socioeconomic status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p><jats:italic>Z<\/jats:italic>\u2010scores were generated for diaphyseal length measurements of six limb bones. Differences between mean <jats:italic>z<\/jats:italic>\u2010score values of the limbs, as well as of the proximal and distal segments of each limb, were assessed using paired samples <jats:italic>t<\/jats:italic>\u2010tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The lower limb was significantly more stunted in growth relative to the upper limb (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.001), as was the distal segment of the upper limb relative to the proximal segment (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.001). In contrast, the distal segment of the lower limb was significantly less stunted in growth relative to the proximal segment (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The findings of increased sensitivity in the lower limb relative to the upper limb and in the distal segment of the upper limb relative to its proximal segment are consistent with the laws of developmental direction. However, the finding of greater sensitivity in the proximal segment of the lower limb relative to the distal segment does not align with the theorized developmental gradient. These results reveal the complexity of human growth and developmental plasticity in response to biocultural factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajpa.25047","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T05:15:46Z","timestamp":1735190146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Laws of Developmental Direction Using a Documented Skeletal Collection"],"prefix":"10.1002","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9795-0779","authenticated-orcid":false,"given":"Jennifer S.","family":"Nelson","sequence":"first","affiliation":[{"name":"University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-4057","authenticated-orcid":false,"given":"Lesley","family":"Harrington","sequence":"additional","affiliation":[{"name":"University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Holland","sequence":"additional","affiliation":[{"name":"Brandon University  Brandon Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-101X","authenticated-orcid":false,"given":"Hugo F. 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