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Characterized by symptoms such as polycystic ovaries, anovulation, and hyperandrogenism, PCOS remains challenging to diagnose, particularly in its early stages. Research suggests that women with PCOS may experience earlier onset of menarche, but the mechanisms behind this association are not well understood. This study explores whether early menarche could serve as an effective diagnostic marker for PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A survey was conducted with 95 adult women (ages 19\u201362), divided into two groups: women diagnosed with PCOS (49%, <jats:italic>n<\/jats:italic>\u2009=\u200947) and women without PCOS (51%, <jats:italic>n<\/jats:italic>\u2009=\u200948). Participants with PCOS self\u2010identified and were required to meet the Rotterdam Criteria for diagnosis. Notably, all self\u2010identified participants with PCOS exhibited the hyperandrogenic phenotype. Independent samples <jats:italic>t<\/jats:italic>\u2010tests and linear regression were used for data analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with PCOS reached menarche an average of 1.8\u2009years earlier than those without the condition (mean age 11.4\u2009\u00b1\u20091.6\u2009years vs. 13.2\u2009\u00b1\u20091.2\u2009years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These findings suggest that early menarche may be a promising, underexplored indicator of PCOS, offering a potential new avenue for earlier diagnosis of the condition. This could be particularly valuable, as PCOS is often not diagnosed until more classic symptoms, such as anovulation or hirsutism, emerge. Further research is needed to confirm these results and investigate the underlying mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajpa.70046","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T07:36:29Z","timestamp":1744702589000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Age at Menarche and Its Potential Role in Early Detection of Hyperandrogenic Polycystic Ovary Syndrome"],"prefix":"10.1002","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3924-091X","authenticated-orcid":false,"given":"C.","family":"Manthey","sequence":"first","affiliation":[{"name":"The University of Montana  Missoula Montana USA"},{"name":"The University of Colorado Colorado Springs  Colorado Springs Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7031-5281","authenticated-orcid":false,"given":"C. 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