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We also assessed their use as predictors of viability at 12 weeks gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Exploratory secondary analysis of a prospective study including all women classified as a pregnancy of known location (<jats:styled-content style=\"fixed-case\">PUL<\/jats:styled-content>) based on transvaginal ultrasonography between January and December 2007 at the early pregnancy unit of St Georges\u2019 Hospital (London). We used multinomial logistic regression to assess the diagnostic potential of the biomarkers to triage <jats:styled-content style=\"fixed-case\">PUL<\/jats:styled-content> at high risk of complications (<jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content> or persistent <jats:styled-content style=\"fixed-case\">PUL<\/jats:styled-content>), and standard binary logistic regression to predict first trimester viability at 12 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For discriminating high\u2010risk (n = 16) from low\u2010risk <jats:styled-content style=\"fixed-case\">PUL<\/jats:styled-content> (n = 93), the area under the receiver operating characteristic curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) was 0.75 (95% confidence interval 0.60\u20130.85) for activin B and 0.55 (0.41\u20130.68) for <jats:styled-content style=\"fixed-case\">FN<\/jats:styled-content>1. Adding activin B to a multinomial logistic regression model incorporating \u03b2\u2010<jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content> ratio and initial progesterone yielded odds ratios of 0.16 (0.05\u20130.55) for failing vs high\u2010risk <jats:styled-content style=\"fixed-case\">PUL<\/jats:styled-content> and 0.29 (0.07\u20131.19) for intrauterine vs high\u2010risk <jats:styled-content style=\"fixed-case\">PUL<\/jats:styled-content> and increased the model's <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> from 0.84 to 0.89. At a risk threshold of 5% for high\u2010risk <jats:styled-content style=\"fixed-case\">PUL<\/jats:styled-content>, sensitivity increased from 84% to 87% and specificity from 48% to 64%. For discriminating viable (n = 28) from non\u2010viable (n = 81) pregnancies at 12 weeks, both markers had an <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> of 0.54.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggested that activin B may be a promising marker to improve <jats:styled-content style=\"fixed-case\">PUL<\/jats:styled-content> triage in addition to established markers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajum.12090","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T03:14:09Z","timestamp":1524712449000},"page":"138-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The potential value of activin B and fibronectin for the triage of pregnancies of unknown location and prediction of first trimester viability"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3662-3010","authenticated-orcid":false,"given":"Maya","family":"Al\u2010Memar","sequence":"first","affiliation":[{"name":"Tommy's National Centre for Miscarriage Research Queen Charlotte's &amp; 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