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It may range from the complete phenotype of <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> characterised by short stature, ovarian failure, cardiac and renal abnormalities, with milder variants often associated with mosaic <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We describe five cases of <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In case 1, complete <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> was identified by first\u2010trimester screening with a grossly oedematous fetus at 11\u00a0weeks of gestation and underwent medical termination of pregnancy due to the dismal prognosis. In case 2, a hydropic fetus and large cystic hygromas were identified at routine second\u2010trimester morphology scan. Intra\u2010uterine fetal death was identified at 22\u00a0weeks of gestation and formal karyotype confirmed complete <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>. Case 3 demonstrates the potential for a successful live birth of mosaic <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> with mild neurocognitive and renal abnormalities. Case 4 demonstrates the ability for <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> to go undetected until adolescence where the patient was diagnosed at 15\u00a0years of age during investigations for severe anaemia, identified as secondary to critical aortic stenosis and Heyde's syndrome. Case 5 highlights the potential for patients with <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> to reproduce with assisted reproductive technology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These cases explore the prognostic spectrum of <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> and highlight that they have a potential to lead productive and fulfilling lives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Consequently, a multimodal risk stratification approach to prognostic counselling should be under\u2010taken with consideration of pertinent history, major sonographic abnormalities, maternal serum testing and invasive testing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajum.12098","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T12:44:53Z","timestamp":1529585093000},"page":"219-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Turner syndrome \u2013 The clinical spectrum and management dilemmas"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6644-6839","authenticated-orcid":false,"given":"Krishanthy","family":"Thayalan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Redcliffe Hospital Anzac Avenue Redcliffe 4020 Australia"},{"name":"The University of Queensland St Lucia Queensland 4072 Australia"},{"name":"James Cook University 1 James Cook Dr Douglas Queensland 4814 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3986-5875","authenticated-orcid":false,"given":"Kimberly","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Redcliffe Hospital Anzac Avenue Redcliffe 4020 Australia"},{"name":"The University of Queensland St Lucia Queensland 4072 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alka","family":"Kothari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Redcliffe Hospital Anzac Avenue Redcliffe 4020 Australia"},{"name":"The University of Queensland St Lucia Queensland 4072 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2012.3931"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2015.07.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05487-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2006.25.6.711"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853899908998785"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"43","article-title":"Nuchal thickening or cystic hygromas in first\u2010and early second\u2010trimester fetuses: prognosis and outcome","volume":"82","author":"Nadel A","year":"1993","journal-title":"Obstet Gynecol"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.230"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853899908998785"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.2.532"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.03.085"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0055-7"},{"issue":"44","key":"e_1_2_10_13_1","first-page":"2131","article-title":"The role of ultrasonography in second trimester screening for fetal chromosome aberrations","volume":"147","author":"Papp C","year":"2006","journal-title":"Orv Hetil"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000111588"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0004-8666.2003.00025.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-012-0269-9"},{"issue":"7","key":"e_1_2_10_17_1","first-page":"893","article-title":"Echographic diagnosis of cystic hygroma. 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