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In those at high risk for pre\u2010eclampsia, interventions such as aspirin intake have been shown to reduce prevalence of disease. However, to implement these interventions, it is essential that high\u2010risk women be identified early in pregnancy. A combined first trimester screening model for pre\u2010eclampsia that includes maternal history, mean arterial pressure, uterine artery Doppler and Pl<jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content> has been shown to be the most effective at identifying the population at greatest risk of pre\u2010eclampsia. This article will explore the most appropriate methods of measuring the components of first trimester screening and discuss the use of aspirin for prevention of pre\u2010eclampsia in pregnancy.<\/jats:p>","DOI":"10.1002\/ajum.12111","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T07:33:55Z","timestamp":1536564835000},"page":"191-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["How to perform first trimester combined screening for pre\u2010eclampsia"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4251-7193","authenticated-orcid":false,"given":"Maya","family":"Reddy","sequence":"first","affiliation":[{"name":"Perinatal Services Monash Medical Centre 246 Clayton Road Clayton Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology Monash University 246 Clayton Road Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward Andrew","family":"Springhall","sequence":"additional","affiliation":[{"name":"Perinatal Services Monash Medical Centre 246 Clayton Road Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2263-3592","authenticated-orcid":false,"given":"Daniel Lorber","family":"Rolnik","sequence":"additional","affiliation":[{"name":"Perinatal Services Monash Medical Centre 246 Clayton Road Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricio","family":"da Silva Costa","sequence":"additional","affiliation":[{"name":"Perinatal Services Monash Medical Centre 246 Clayton Road Clayton Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology Monash University 246 Clayton Road Clayton Victoria Australia"},{"name":"Monash Ultrasound for Women Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,10]]},"reference":[{"issue":"4","key":"e_1_2_10_2_1","first-page":"281","article-title":"Principles and practice of mass screening for disease","volume":"65","author":"Wilson JM","year":"1968","journal-title":"Bol Oficina Sanit Panam"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.010"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181a45b25"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.04.032"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704559"},{"key":"e_1_2_10_7_1","volume-title":"The management of hypertensive disorders during pregnancy","author":"Hypertension in Pregnancy","year":"2010"},{"issue":"5","key":"e_1_2_10_8_1","first-page":"1122","article-title":"Hypertension in pregnancy. 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