{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:45:35Z","timestamp":1789076735901,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australas J Ultrason Med"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Choroid plexus cysts (<jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>) and echogenic intracardiac focus (<jats:styled-content style=\"fixed-case\">EIF<\/jats:styled-content>) are obsolete soft markers found on morphology ultrasound and not a valid reason for adjusting fetal risk of aneuploidy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We conducted a retrospective audit of women referred to genetic counsellor and fetal medicine services at St George Hospital (<jats:styled-content style=\"fixed-case\">SGH<\/jats:styled-content>) and the Royal Hospital for Women (<jats:styled-content style=\"fixed-case\">RHW<\/jats:styled-content>) for <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EIF<\/jats:styled-content> from 1 January 2006 to 31 December 2016 inclusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 208 <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">EIF<\/jats:styled-content> referrals were identified, 118 (57%) of which were for isolated <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">EIF<\/jats:styled-content> and 102 (49%) occurring in women low risk for aneuploidy prior to morphology ultrasound. Significantly, more women had undergone combined first\u2010trimester screening in the 2014 to 2016 epoch vs. previous years at both <jats:styled-content style=\"fixed-case\">SGH<\/jats:styled-content> (P\u00a0=\u00a00.03) and <jats:styled-content style=\"fixed-case\">RHW<\/jats:styled-content> (P\u00a0=\u00a00.004). However, the number of women referred for <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EIF<\/jats:styled-content> remained relatively constant. No fetus was born with a major structural or chromosomal abnormality in the group of low\u2010risk women with isolated signs. However, 18% of these women were referred to both genetic counselling and fetal medicine services, 7% had <jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content> after morphology, 14% had amniocentesis, and 33% had additional ultrasound(s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite advances in screening technology, low\u2010risk women are still referred to specialist services for these 2 soft signs and undergoing unnecessary follow\u2010up, <jats:styled-content style=\"fixed-case\">NIPT<\/jats:styled-content> and amniocentesis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajum.12180","type":"journal-article","created":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T06:54:15Z","timestamp":1570863255000},"page":"253-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Isolated \u2018soft signs\u2019 of fetal choroid plexus cysts or echogenic intracardiac focus 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