{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:37:45Z","timestamp":1769045865614,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000762","name":"Imperial College Healthcare NHS Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000761","name":"Imperial College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australas J Ultrason Med"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Polyhydramnios is common; the majority of cases are idiopathic, but maybe associated with fetal abnormality. Literature suggests the volume of amniotic fluid discriminates idiopathic from pathological polyhydramnios but is not unanimous. We assessed fetal anomaly incidence amongst women with polyhydramnios and the role of discriminatory variables in identifying pathological cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective observational cohort study at an inner\u2010city London fetal medicine centre. Records for patients referred and\/or diagnosed with polyhydramnios were reviewed as well as maternal\/fetal demographics, amongst singleton pregnancies using the Astraia\u2122 database from January 2015\u20132016. Estimated fetal weight was calculated using the Hadlock model (biometry undertaken at diagnosis). Student's t\u2010test\/one\u2010way ANOVA compared means; chi\u2010squared tests compared proportions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>120 cases were identified. 36 (30%) had fetal abnormality. There was no difference in AFI between fetuses with an abnormality and without (26.7 vs 25.2\u00a0cm, P\u00a0=\u00a00.22). AFI was normalised for weight (AFI (cm)\/estimated fetal weight (kg)): AFI\/kg was significantly different between cases with fetal abnormality and without (24.4 vs 16.7\u00a0cm\/kg, P\u00a0&lt;\u00a00.001) \u2013 incidence of abnormality increased with increasing AFI\/kg (P\u00a0=\u00a00.007). Early gestational diagnosis was associated with higher rates of anomaly (P\u00a0=\u00a00.004). Differences in AFI\/kg between those with and without abnormality were not significant when adjusted for gestation. AFI was significantly higher in cases of abnormality diagnosed at later gestation (P\u00a0=\u00a00.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Excess volume of amniotic fluid alone does not denote abnormality. Earlier gestations and higher AFI\/kg corresponded with significantly increased rates of anomaly. However, the latter is a result of confounding by gestation, which is closely correlated with fetal weight.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajum.12247","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T12:48:24Z","timestamp":1622033304000},"page":"137-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Contemporary experience of polyhydramnios: A single\u2010centre experience"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9001-5545","authenticated-orcid":false,"given":"Christopher","family":"Kyriacou","sequence":"first","affiliation":[{"name":"Tommy's National Centre for Miscarriage Research Queen Charlotte's &amp; Chelsea Hospital Imperial College London UK"},{"name":"Institute for Reproductive and Developmental Biology Imperial College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1968-2924","authenticated-orcid":false,"given":"Louise","family":"Roper","sequence":"additional","affiliation":[{"name":"Centre for Fetal Care Queen Charlotte's &amp; Chelsea Hospital Imperial College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Mappouridou","sequence":"additional","affiliation":[{"name":"Centre for Fetal Care Queen Charlotte's &amp; Chelsea Hospital Imperial College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Lees","sequence":"additional","affiliation":[{"name":"Institute for Reproductive and Developmental Biology Imperial College London UK"},{"name":"Centre for Fetal Care Queen Charlotte's &amp; Chelsea Hospital Imperial College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Prior","sequence":"additional","affiliation":[{"name":"Institute for Reproductive and Developmental Biology Imperial College London UK"},{"name":"Centre for Fetal Care Queen Charlotte's &amp; Chelsea Hospital Imperial College London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70084-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ogx.0000290349.58707.e0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tog.12113"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90009-V"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000010129"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/2277-9175.145751"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/2156-7514.106614"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00732.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200207000-00021"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"21","article-title":"Polyhydramnios: ultrasonically detected prevalence and neonatal outcome","volume":"69","author":"Hill LM","year":"1987","journal-title":"Obstet Gynecol."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10093"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970110824"}],"container-title":["Australasian Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajum.12247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajum.12247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajum.12247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T01:22:10Z","timestamp":1692580930000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajum.12247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,26]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/ajum.12247"],"URL":"https:\/\/doi.org\/10.1002\/ajum.12247","archive":["Portico"],"relation":{},"ISSN":["1836-6864","2205-0140"],"issn-type":[{"value":"1836-6864","type":"print"},{"value":"2205-0140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,26]]},"assertion":[{"value":"2020-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}