{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:04:24Z","timestamp":1783382664461,"version":"3.54.6"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T00:00:00Z","timestamp":1661040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australas J Ultrason Med"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Purpose<\/jats:title><jats:p>To evaluate the endometrial thickness (ET) as a predictor of endometrial abnormalities in postmenopausal women and whether consideration of baseline risk factors increases diagnostic accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective observational study of postmenopausal women presenting with bleeding or thickened endometrium (\u22654\u2009mm) on ultrasound, between 2003 and 2012. Risk factors for endometrial abnormality were analysed using logistic regression. Of 301 women, 220 were symptomatic and 81 were asymptomatic. The median ET was 6\u2009mm (IQR 4\u20139) for symptomatic women and 9\u2009mm (IQR 6\u201312) for asymptomatic women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Abnormal pathology was found in 35 symptomatic (15.9%) and 6 asymptomatic women (7.4%). For each 1\u2009mm increase in ET, the odds of an abnormal diagnosis increased by 16.3% (95% CI 9.6\u201323.5) for symptomatic and 19.9% (95% CI 3.1\u201339.3) for asymptomatic women. The Youden's index method identified an ET threshold of \u22657.1mm for symptomatic and \u226514.5mm for asymptomatic women. In symptomatic women the sensitivity was 88.6% (95% CI 72.3\u201396.3) and specificity 69.2% (95% CI 61.9\u201375.6), while in asymptomatic women the sensitivity was 50.0% (95% CI 13.9\u201386.1) and specificity was 89.3% (95% CI 79.5\u201395.0). The addition of age in the symptomatic women model reduced the sensitivity (82.9% (95% CI 65.7\u201392.8)) but increased the specificity (72.4% (95% CI 65.3\u201378.6)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ET is a significant predictor of abnormality. In the absence of risk factors, our study suggests that invasive procedures may be withheld until the ET is \u22657.1\u2009mm with bleeding and \u226514.5\u2009mm in asymptomatic women with no bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajum.12311","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T12:18:50Z","timestamp":1661084330000},"page":"186-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of endometrial thickness by transvaginal ultrasound and baseline risk factors as a predictor for endometrial abnormalities in postmenopausal women"],"prefix":"10.1002","volume":"25","author":[{"given":"Jyothirmayi","family":"Yerrisani","sequence":"first","affiliation":[{"name":"Logan Hospital  Meadowbrook Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1955-7522","authenticated-orcid":false,"given":"Anoushka","family":"Kothari","sequence":"additional","affiliation":[{"name":"James Cook University  Townsville Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4399-3167","authenticated-orcid":false,"given":"Kelly","family":"Collins","sequence":"additional","affiliation":[{"name":"Northwest Private Hospital  Everton Park Queensland Australia"},{"name":"The Wesley Hospital  Auchenflower Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9430-2485","authenticated-orcid":false,"given":"Emma","family":"Ballard","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-3734","authenticated-orcid":false,"given":"Alka","family":"Kothari","sequence":"additional","affiliation":[{"name":"Redcliffe Hospital  Redcliffe Queensland Australia"},{"name":"The University of Queensland  St Lucia Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002631"},{"issue":"5","key":"e_1_2_13_4_1","first-page":"Cd008830","article-title":"Hormone replacement therapy for women previously treated for endometrial cancer","volume":"5","author":"Edey KA","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_13_5_1","unstructured":"Uterine sarcoma: Queensland Government;2020. 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