{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T23:10:36Z","timestamp":1770073836272,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australas J Ultrason Med"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Post\u2010induction hypotension (PIH) is a common complication following anaesthetic induction and is associated with adverse perioperative outcomes. Ultrasound\u2010generated inferior vena cava collapsibility index (IVC\u2010CI) is a non\u2010invasive measure of volume status that may predict PIH. This systematic review and meta\u2010analysis evaluated the diagnostic accuracy of IVC\u2010CI in predicting PIH in adult, non\u2010obstetric patients undergoing general anaesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of PubMed, Embase, and Cochrane Library (up to June 2024) identified studies reporting IVC\u2010CI as a predictor of PIH. Prospective and retrospective observational studies were included, while studies involving paediatric, obstetric, or hypotensive patients pre\u2010induction were excluded. The QUADAS\u20102 tool assessed risk of bias and the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework was utilised to assess certainty of evidence. Pooled diagnostic performance was measured via area under the receiver operating characteristic curve (AUROC). Meta\u2010regression explored heterogeneity across studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010three studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091973) were included, with 16 studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091585) providing AUROC data. The pooled AUROC for IVC\u2010CI in predicting PIH was 0.72 (95% CI, 0.64\u20130.80), indicating moderate diagnostic accuracy. High heterogeneity was observed (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      =\u200994.4%). Meta\u2010regression showed no significant associations between AUROC and age, sex, American Society of Anesthesiologists status, or induction agents. Publication bias was identified (Egger's test,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The quality of evidence, as evaluated using the GRADE approach, was \u2018very low\u2019.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>IVC\u2010CI shows potential as a predictive tool for PIH; however, significant heterogeneity, inconsistent protocols, and publication bias limit its robustness. Standardised measurement methods and larger studies are needed to confirm its clinical utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ultrasound\u2010generated IVC\u2010CI demonstrates moderate accuracy in predicting PIH and may assist in guiding pre\u2010induction management strategies, such as fluid administration or vasopressor use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajum.70033","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T10:00:16Z","timestamp":1769767216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Accuracy of Ultrasound\u2010Generated Inferior Vena Cava Collapsibility Index in the Prediction of Post\u2010Induction Hypotension During General Anaesthesia: A Systematic Review and 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Caragata","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Austin Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Austin Hospital  Melbourne Victoria 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