{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:11:30Z","timestamp":1792059090370,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T00:00:00Z","timestamp":1297123200000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammation\/polyp recurrence, adhesions, and middle turbinate lateralization are causes of suboptimal outcomes following sinus surgery and lead to increased rates of revision. A bioabsorbable, drug\u2010eluting stent was evaluated for its ability to preserve sinus patency by providing controlled steroid delivery to the sinus mucosa. The study objective was to assess safety and efficacy of a steroid\u2010eluting sinus stent when used following functional endoscopic sinus surgery (FESS) in patients with chronic rhinosinusitis (CRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective, multicenter, randomized, double\u2010blind clinical trial, enrolling 43 patients in 2 groups. One group (n = 38) used an intrapatient control design comparing drug\u2010eluting to non\u2010drug\u2010eluting stents. The other group (n = 5) received bilateral drug\u2010eluting stents to assess systemic safety. Endoscopic follow\u2010up was performed for 60 days. Efficacy endpoints included assessment of inflammation, polyp formation, adhesions, and middle turbinate position.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Stents were successfully deployed in all 86 sinuses. Compared to the control stent, the drug\u2010eluting stent provided statistically significant reduction in inflammation at days 21 to 45 (<jats:italic>p<\/jats:italic> &lt; 0.003), frequency of polyp formation (<jats:italic>p<\/jats:italic> = 0.0391), and frequency of significant adhesion (<jats:italic>p<\/jats:italic> = 0.0313). Reduced frequency of middle turbinate lateralization was also apparent though not statistically significant. No device\u2010related adverse events occurred. Eluted steroid was unquantifiable systemically and there was no evidence of adrenal cortical suppression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates the safety and efficacy of a novel bioabsorbable, steroid\u2010eluting stent for use in CRS patients. The steroid\u2010eluting stent is effective in improving wound healing by preserving sinus patency, reducing inflammation, and minimizing adhesions via controlled local steroid delivery without measurable systemic exposure. \u00a9 2011 ARS\u2010AAOA, LLC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.20020","type":"journal-article","created":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T11:40:30Z","timestamp":1297251630000},"page":"23-32","source":"Crossref","is-referenced-by-count":162,"title":["Safety and efficacy of a novel bioabsorbable, steroid\u2010eluting sinus stent"],"prefix":"10.1002","volume":"1","author":[{"given":"Andrew H.","family":"Murr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter 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