{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T15:09:34Z","timestamp":1751987374492},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T00:00:00Z","timestamp":1297123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nasal polyps in patients with cystic fibrosis (CF) are believed to be phenotypically different than polyps affecting non\u2010CF patients. The objective of this study was to characterize the expression of inflammatory cytokines within nasal polyps from CF and non\u2010CF, aspirin\u2010tolerant patients. \u201cRegulated on activation, normal T\u2010cell expressed and secreted\u201d (RANTES) is a chemotactic cytokine involved in the recruitment and activation of eosinophils. Multiple molecular studies of non\u2010CF polyps have established that RANTES may play an important role in nasal polyposis. Our study suggests RANTES may be upregulated in CF polyps relative to non\u2010CF polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nasal polyps were prospectively obtained from CF and non\u2010CF, aspirin\u2010tolerant patients. The Quantibody\u2122 Human Cytokine Array I from RayBiotech, Inc., was used to identify differences in cytokine expression between protein extracts of two polyp groups. Four CF polyp extracts and 4 non\u2010CF, aspirin\u2010tolerant polyp extracts were each incubated on identical antibody subarrays, each containing 20 human cytokines in quadruplicate. Western blot analysis confirmed expression of RANTES.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The protein microarray suggests a greater than 4\u2010fold upregulation of RANTES in CF polyps relative to non\u2010CF polyps. Western blot analysis confirmed expression of RANTES in CF polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chemokines such as RANTES are responsible for the activation of inflammatory cells within the lamina propria of nasal polyps. We have demonstrated that RANTES may be an important cytokine associated with CF polyps. \u00a9 2011 ARS\u2010AAOA, LLC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.20027","type":"journal-article","created":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T11:40:39Z","timestamp":1297251639000},"page":"157-160","source":"Crossref","is-referenced-by-count":4,"title":["Upregulation of RANTES in nasal polyps from patients with cystic fibrosis"],"prefix":"10.1002","volume":"1","author":[{"given":"Victor I.","family":"Scapa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay R.","family":"Ramakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela A.","family":"Mudd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd T.","family":"Kingdom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-9725.2003.00061.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2005.08.010"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459988709700403"},{"key":"e_1_2_6_5_2","first-page":"1067","article-title":"Treatment and prognosis of nasal polyps in cystic fibrosis","volume":"136","author":"Stern R","year":"1982","journal-title":"Am J Dis Child."},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600403"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2001.21006"},{"key":"e_1_2_6_8_2","first-page":"445","article-title":"Differential pathology of nasal polyps in cystic fibrosis and atopy","volume":"40","author":"Oppenheimer E","year":"1979","journal-title":"Lab Invest."},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1028"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6200"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112787"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200008000-00025"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949910800612"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348949810700510"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/194589240501900103","article-title":"The role of RANTES in nasal polyposis","volume":"19","author":"Meyer JE","year":"2005","journal-title":"Am J Rhinol Allergy."},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3314"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200404000-00013"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1152\/ajpcell.1999.276.3.C700","article-title":"Chemokine expression in CF epithelia: implications for the role of CFTR in RANTES expression","volume":"276","author":"Schweibert LM","year":"1999","journal-title":"Am J Physiol."},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200207-765OC"},{"key":"e_1_2_6_20_2","first-page":"307","volume":"23","author":"Leidal KG","year":"2003","journal-title":"Metalloproteases from Pseudomonas aeruginosa degrade human RANTES, MCP\u20101, and ENA\u201078"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0069OC"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.2.594-606.2003"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.20027","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.20027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T14:46:27Z","timestamp":1700491587000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.20027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,8]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1002\/alr.20027"],"URL":"https:\/\/doi.org\/10.1002\/alr.20027","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,8]]}}}