{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:10:30Z","timestamp":1780924230552,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T00:00:00Z","timestamp":1323734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Persistent infection following endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) is a frustrating entity for the patient and rhinologist alike. Mupirocin nasal washes have been proposed as an efficacious treatment in such patients. Two small studies have reported excellent short\u2010term posttreatment outcomes; however, the long\u2010term microbiological outcomes following treatment are not known; likewise, the rate of mupirocin\u2010resistance following treatment has not been explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This was a retrospective chart review of 61 patients with\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      (\n                      <jats:italic>S. aureus<\/jats:italic>\n                      )\u2010positive surgically\u2010recalcitrant CRS having undergone 0.05% mupirocin nasal rinse treatment, twice daily for 4 weeks. Specific outcomes reported included posttreatment culture results, time to first posttreatment\n                      <jats:italic>S. aureus<\/jats:italic>\n                      culture, and mupirocin\u2010sensitivity following treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 57 patients meeting minimal posttreatment follow\u2010up criteria, 42 (73.7%) progressed to microbiological failure by subsequently cultured\n                      <jats:italic>S. aureus<\/jats:italic>\n                      . Mean time to first positive culture was 144 days. Of the 42 patients who progressed to microbiological relapse, full antibiotic sensitivity data was available for 41; of these, only 1 was found to subsequently harbor a mupirocin\u2010resistant strain of\n                      <jats:italic>S. aureus<\/jats:italic>\n                      , thus yielding a posttreatment resistance rate of 2.4%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Treatment with mupirocin nasal washes in\n                      <jats:italic>S. aureus<\/jats:italic>\n                      \u2013positive, surgically recalcitrant CRS has a high microbiological failure rate, with 73.7% of patients subsequently re\u2010culturing\n                      <jats:italic>S. aureus<\/jats:italic>\n                      . Our current treatment regime of 0.05% nasal washes twice daily for 4 weeks is associated with a posttreatment resistance rate that is consistent with other studies of topical mupirocin use, suggesting that mupirocin washes are no more likely to induce resistance than nasal vestibule decolonization in the high\u2010risk medical or surgical patient. \u00a9 2011 ARS\u2010AAOA, LLC.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.20106","type":"journal-article","created":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T19:43:17Z","timestamp":1323805397000},"page":"111-115","source":"Crossref","is-referenced-by-count":49,"title":["Microbiological outcomes following mupirocin nasal washes for symptomatic,\n                    <i>Staphylococcus aureus<\/i>\n                    \u2013positive chronic rhinosinusitis following endoscopic sinus surgery"],"prefix":"10.1002","volume":"2","author":[{"given":"Joshua","family":"Jervis\u2010Bardy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter\u2010John","family":"Wormald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.125.10.1117"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000210"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2005.08.006"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.11.011"},{"key":"e_1_2_6_6_2","first-page":"249","article-title":"Intracellular residency is frequently associated with recurrent Staphylococcus aureus rhinosinusitis","volume":"44","author":"Plouin\u2010Gaudon I","year":"2006","journal-title":"Rhinology"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31817aec47"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2005.09.006"},{"key":"e_1_2_6_9_2","first-page":"387","article-title":"Mupirocin\u2010resistant Staphylococcus aureus","volume":"2","author":"Baird D","year":"1987","journal-title":"Lancet"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92398-1"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/502427"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/520663"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg127"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/501594"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.6.2792-2795.2004"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2010.06.023"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3265"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3366"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20050"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46965-0"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.01.005"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3122"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3232"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21717"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21024"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2009.07.005"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21438"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31815bf2e3"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808939"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/35.3.399"},{"key":"e_1_2_6_31_2","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1001\/archinte.1994.00420130101013","article-title":"Long\u2010term efficacy of intranasal mupirocin ointment. 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