{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:30:32Z","timestamp":1792157432872,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Endoscopic skull base surgery (ESBS) is considered a minimally\u2010invasive surgical modality with less morbidity and patient discomfort. Quality\u2010of\u2010life (QOL) assessments provide a patient\u2010reported estimate of well\u2010being that may be clinically relevant. Although the sinonasal tract is integral to ESBS, the change in sinonasal\u2010related QOL with ESBS has not been well studied. The aim of this study was to prospectively assess QOL before and after ESBS using validated outcome measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Consecutive adult patients undergoing ESBS for anterior skull base lesions were prospectively enrolled from a tertiary referral center. Each patient was asked to complete the 22\u2010item Sinonasal Outcome Test (SNOT\u201022) and the Anterior Skull Base Questionnaire (ASBQ) preoperatively, and again at 3 weeks, 6 weeks, 12 weeks, 6 months, and 1 year postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Eighty\u2010five patients were included for study, 44.7% of whom underwent ESBS for nonpituitary pathology. Mean SNOT\u201022 scores transiently worsened in the early postoperative period, and significantly improved at 1 year after surgery (<jats:italic>p<\/jats:italic> &lt; 0.01). Gross\u2010total tumor resection and use of autologous grafting materials were associated with improved SNOT\u201022 scores at later time points (<jats:italic>p<\/jats:italic> &lt; 0.05). Type of reconstruction, tumor pathology, and functionality did not affect QOL scores. Correlation between SNOT\u201022 and ASBQ scores was good at all time points (<jats:italic>r<\/jats:italic> &lt; \u22120.50). Cerebrospinal fluid leak and other complications were uncommon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>ESBS does not have a detrimental long\u2010term effect and is associated with ultimate improvement in sinonasal\u2010related QOL. Short\u2010term impairments of sinonasal\u2010related QOL are predictable and self\u2010limited. Prospective assessment using sinonasal\u2010related and site\u2010specific QOL instruments provide complementary information about ESBS outcomes. \u00a9 2012 ARS\u2010AAOA, LLC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21008","type":"journal-article","created":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T19:28:14Z","timestamp":1326828494000},"page":"174-181","source":"Crossref","is-referenced-by-count":89,"title":["Endoscopic skull base surgery and its impact on sinonasal\u2010related quality of life"],"prefix":"10.1002","volume":"2","author":[{"given":"Edward D.","family":"McCoul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay K.","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Bedrosian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore H.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,17]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"126","article-title":"Microscopic versus endoscopic transnasal pituitary surgery","volume":"142","author":"Schaberg MR","year":"2010","journal-title":"Curr Opin Otolaryngol Head Neck Surg."},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.0080.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1242979"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20029"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.12.1303"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1242983"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940911800905"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.98.2.0350"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:PITU.0000004798.27230.ed"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1058"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21483"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000325861.06832.06"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.11.012"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3180caa177"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2006.01155.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.121022"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1180-8"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.01.024"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2004.100.5.0813"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.11.1276"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1242982"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21008","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T06:38:48Z","timestamp":1700548728000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,17]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1002\/alr.21008"],"URL":"https:\/\/doi.org\/10.1002\/alr.21008","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,17]]}}}