{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T23:10:53Z","timestamp":1787440253303,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) can be compromised by postoperative inflammation, polyposis, and adhesions, often requiring subsequent interventions. A bioabsorbable, steroid\u2010releasing sinus implant has been studied in 2 prospective, randomized clinical trials for its ability to preserve sinus patency and reduce medical and surgical interventions after ESS in patients with CRS. The objective of this study was to perform a meta\u2010analysis of the efficacy results from the 2 trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>The 2 prospective, randomized, double\u2010blinded, multicenter trials enrolled a total of 143 patients utilizing an intrapatient control design. Postoperative day 30 videos were obtained for each patient, randomly ordered, and presented to an independent panel of 3 otolaryngologists for grading of efficacy endpoints. The need for postoperative interventions, formation of polyposis, and adhesions were assessed. Results from the 2 studies were then pooled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Implants were successfully placed in all 286 ethmoid sinuses. According to the grading done by the panel, drug\u2010releasing implants reduced postoperative interventions by 35% (<jats:italic>p<\/jats:italic> = 0.0008), lysis of adhesions by 51% (<jats:italic>p<\/jats:italic> = 0.0016), and oral steroid need by 40% (<jats:italic>p<\/jats:italic> = 0.0023), compared to controls. The relative reduction in frank polyposis was 46% (<jats:italic>p<\/jats:italic> &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Early postoperative healing is a predictor of longer\u2010term success after sinus surgery. Evaluation of postoperative outcomes by a blinded independent panel demonstrates that steroid\u2010releasing implants that provide a sustained release of corticosteroid improve surgical outcomes by reducing frank polyp formation, sinus adhesions, and middle turbinate lateralization. Steroid\u2010releasing implants reduce the need for surgical intervention, and the need for oral steroid treatment. \u00a9 2012 ARS\u2010AAOA, LLC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21044","type":"journal-article","created":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T04:52:42Z","timestamp":1335934362000},"page":"271-279","source":"Crossref","is-referenced-by-count":95,"title":["Effect of steroid\u2010releasing sinus implants on postoperative medical and surgical interventions: an efficacy meta\u2010analysis"],"prefix":"10.1002","volume":"2","author":[{"given":"Joseph K.","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley F.","family":"Marple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H.","family":"Murr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent J.","family":"Lanier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Stambaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Mugglin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199901000-00006"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2008.12.006"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000184581.67185.6e"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20905"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3171"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20020"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22228"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200003002-00008"},{"key":"e_1_2_7_10_2","article-title":"Advance II: a prospective, randomized study assessing safety and efficacy of bioabsorbable steroid\u2010releasing sinus implants","author":"Marple BF","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01463560"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21044","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T06:26:01Z","timestamp":1700547961000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1002\/alr.21044"],"URL":"https:\/\/doi.org\/10.1002\/alr.21044","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}