{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T07:33:26Z","timestamp":1776929606517,"version":"3.51.2"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T00:00:00Z","timestamp":1349308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) is a heterogeneous disease defined by epithelial inflammation. The link between measures of traditional disease severity and markers of epithelial inflammation is poorly understood as prior research has focused on presence of polyps or degree of eosinophilia. The expression of 3 epithelial derived cytokines implicated in initiation of T\u2010helper 2 (Th2) inflammation and an eosinophil chemoattractant were compared with clinical measures used in CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sinus mucosal samples from CRS patients undergoing sinus surgery were analyzed for interleukin\u201025 (IL\u201025), IL\u201033, thymic stromal lymphopoietin (TSLP), and eotaxin\u20103 messenger RNA (mRNA) expression by quantitative polymerase chain reaction (PCR). Tumor patients undergoing surgery transnasally with normal sinus mucosa were controls. Gene expression was compared with symptom, radiology, and endoscopy scores, serological markers, presence of reactive airways disease (RAD), and atopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven patients (38% female, mean age 48 \u00b1 15 years), 12 CRS with nasal polyps (CRSwNP), 18 CRS without nasal polyps (CRSsNP), and 7 controls were recruited. CRSwNP phenotype predicted elevated IL\u201025, IL\u201033, and eotaxin\u20103 levels. Increased eotaxin\u20103 correlated with poorer computed tomography (CT) (<jats:italic>p<\/jats:italic> = 0.004) and endoscopic scores (<jats:italic>p<\/jats:italic> = 0.049). Increased IL\u201025 correlated with poorer CT scores (<jats:italic>p<\/jats:italic> = 0.012) and raised serum eosinophils (<jats:italic>p<\/jats:italic> = 0.006). No associations with RAD, atopy, and symptom measures were found. No associations for IL\u201033 and TSLP were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Inflammatory mediators of the epithelium in CRS has some correlation with traditional measures of disease burden. Certain epithelial profiles may predict highly dysfunctional epithelial barriers and prospective evaluation of the clinical outcomes from interventions is required. Future endotyping of the epithelium in CRS may be able to provide prognostic information.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21082","type":"journal-article","created":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T13:03:05Z","timestamp":1349355785000},"page":"121-128","source":"Crossref","is-referenced-by-count":72,"title":["Clinical severity and epithelial endotypes in chronic rhinosinusitis"],"prefix":"10.1002","volume":"3","author":[{"given":"Matthew","family":"Lam","sequence":"first","affiliation":[{"name":"St Vincent's Clinical School Faculty of Medicine University of New South Wales Sydney Australia"},{"name":"Immunology Department Garvan Institute of Medical Research  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Hull","sequence":"additional","affiliation":[{"name":"St Vincent's Clinical School Faculty of Medicine University of New South Wales Sydney Australia"},{"name":"Immunology Department Garvan Institute of Medical Research  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan","family":"McLachlan","sequence":"additional","affiliation":[{"name":"St Vincent's Clinical School Faculty of Medicine University of New South Wales Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kornkiat","family":"Snidvongs","sequence":"additional","affiliation":[{"name":"Australian School of Advanced Medicine Macquarie University  Sydney Australia"},{"name":"Department of Otolaryngology Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology St Vincent's Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellie","family":"Pratt","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health University of Sydney  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Kalish","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Concord Repatriation General Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Sacks","sequence":"additional","affiliation":[{"name":"Australian School of Advanced Medicine Macquarie University  Sydney Australia"},{"name":"Sydney School of Public Health University of Sydney  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Earls","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology St Vincent's Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Sewell","sequence":"additional","affiliation":[{"name":"St Vincent's Clinical School Faculty of Medicine University of New South Wales Sydney Australia"},{"name":"Immunology Department Garvan Institute of Medical Research  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Harvey","sequence":"additional","affiliation":[{"name":"St Vincent's Clinical School Faculty of Medicine University of New South Wales Sydney Australia"},{"name":"Australian School of Advanced Medicine Macquarie University  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,4]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps group. 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