{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T01:04:59Z","timestamp":1773450299346,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T00:00:00Z","timestamp":1349308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Endoscopic endonasal transcribriform (EET) resection of anterior skull base (ASB) tumors results in large defects that may extend the entirety of the cribriform plate. Endoscopic repair of these cribriform defects can often be challenging. We describe our reconstruction technique for large ASB defects after EET resection of ASB tumors. This triple\u2010layer technique is comprised of autologous fascia lata, acellular dermal allograft, and a vascularized pedicled nasoseptal flap (PNSF). The technique is described and postoperative cerebrospinal fluid (CSF) leak rate is evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review over a 2\u2010year period identified 10 patients who underwent a purely EET approach for resection of ASB tumors. Patients who underwent combined cranionasal approaches and those treated for ASB encephaloceles were excluded from this study. After tumor resection, patients underwent triple\u2010layer reconstruction using autologous fascia lata inlay, acellular dermal allograft inlay\/overlay, followed by a PNSF to reconstruct the cribriform defect. No postoperative lumbar drainage was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average cribriform defect size was 9.1 (range, 5.0\u201313.8) cm<jats:sup>2<\/jats:sup>. All 10 patients underwent successful reconstruction with a postoperative CSF leak rate of 0% without the use of postoperative lumbar drainage. The mean follow\u2010up period was 7.4 (range, 2\u201317) months. The mean age was 45.8 (range, 15\u201381) years with 30% of the patients being females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The triple\u2010layer reconstruction technique is effective in reconstructing large ASB defects after endoscopic resection of the cribriform plate. We feel that the use of postoperative lumbar drainage is not necessary when using this repair technique.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21089","type":"journal-article","created":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T12:59:46Z","timestamp":1349355586000},"page":"204-211","source":"Crossref","is-referenced-by-count":45,"title":["Triple\u2010layer reconstruction technique for large cribriform defects after endoscopic endonasal resection of anterior skull base tumors"],"prefix":"10.1002","volume":"3","author":[{"given":"Jean Anderson","family":"Eloy","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Medicine and Dentistry of New Jersey\u2013New Jersey Medical School  Newark NJ"},{"name":"Department of Neurological Surgery University of Medicine and Dentistry of New Jersey\u2013New Jersey Medical School  Newark NJ"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey University of Medicine and Dentistry of New Jersey\u2013New Jersey Medical School  Newark NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smruti K.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Medicine and Dentistry of New Jersey\u2013New Jersey Medical School  Newark NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratik A.","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Medicine and Dentistry of New Jersey\u2013New Jersey Medical School  Newark NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mickey L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Medicine and Dentistry of New Jersey\u2013New Jersey Medical School  Newark NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamah J.","family":"Choudhry","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Medicine and Dentistry of New Jersey\u2013New Jersey Medical School  Newark NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James K.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Medicine and Dentistry of New Jersey\u2013New Jersey Medical School  Newark NJ"},{"name":"Department of Neurological Surgery University of Medicine and Dentistry of New Jersey\u2013New Jersey Medical School  Newark NJ"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey University of Medicine and Dentistry of New Jersey\u2013New Jersey Medical School  Newark NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240101500410"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3171\/2011.2.FOCUS116"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.3080"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199609000-00015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(03)00031-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2931"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000255354.64077.66"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-959337"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20861"},{"key":"e_1_2_6_11_1","unstructured":"Garcia\u2010NavarroV AnandVK SchwartzTH.Gasket Seal Closure for Extended Endonasal Endoscopic Skull Base Surgery: Efficacy in a Large Case Series. 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