{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:09:07Z","timestamp":1788412147940,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T00:00:00Z","timestamp":1349654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The conventional escalation regimen for sublingual immunotherapy (SLIT) in patients with allergic rhinitis has been proven to be safe and successful in reducing allergic symptoms. However, few studies compared the efficacy and safety between a conventional escalation regimen for SLIT and once\u2010daily SLIT. The aim of the present study was to compare the efficacy and safety of once\u2010daily SLIT without escalation (SLITsE) to conventional escalation therapy (SLITwE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a nonrandomized open label observational study. In total, 153 patients suffering from allergic rhinitis symptoms and sensitized to the perennial house dust mite allergens <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic> and <jats:italic>Dermatophagoides farinae<\/jats:italic>, were enrolled in this study from July 2008 to December 2009. The patients were divided into 2 groups, SLITwE and SLITsE. Each patient was followed with a diary card on which a symptom score, a rescue medication score, and adverse events were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All of the nasal symptoms, including rhinorrhea, sneezing, nasal obstruction, itching, and olfactory symptoms, defined as a total nasal symptom score, were reduced after 6 months in both groups (<jats:italic>p<\/jats:italic> &lt; 0.05). The rescue medication score, defined as the sum of all of the allergy medications used, also decreased in both groups. Adverse events were similar in both groups, and no major adverse events, such as anaphylaxis, were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Once\u2010daily SLITsE was well tolerated and showed safe and comparable efficacy compared with a conventional SLITwE regimen.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21098","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T17:12:33Z","timestamp":1349716353000},"page":"177-183","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy and safety of a once\u2010daily sublingual immunotherapy without escalation regimen in house dust mite\u2013induced allergic rhinitis"],"prefix":"10.1002","volume":"3","author":[{"given":"Sue Jean","family":"Mun","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Seoul National University Hospital College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Min","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Soon Chun Hyang University College of Medicine  Cheonan Chungcheongnamdo Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doo Hee","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Seoul National University Hospital College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Whun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Seoul National University Bundang Hospital  Seongnam Gyeonggido Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Seoul National University Hospital College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Seoul National University Hospital College of Medicine  Seoul Korea"},{"name":"Research Center for Sensory Organs Seoul National University Medical Research Center  Seoul Korea"},{"name":"Institute of Allergy and Clinical Immunology Seoul National University Medical Research Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang\u2010Gi","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Seoul National University Hospital College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae\u2010Seo","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Seoul National University Hospital College of Medicine  Seoul Korea"},{"name":"Department of Otorhinolaryngology Seoul National University Bundang Hospital  Seongnam Gyeonggido 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