{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:39:33Z","timestamp":1779291573869,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T00:00:00Z","timestamp":1352073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Current symptom criteria for identifying patients with chronic rhinosinusitis (CRS) has poor specificity. The objective of this study was to test the hypothesis that symptoms drawn from the Task Force on Rhinosinusitis (RSTF) criteria and the International Headache Society (IHS) criteria for primary headaches can differentiate CRS patients from those with CRS\u2010symptoms but no evidence for inflammation (non\u2010CRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study from a total of 140 charts of patients who received a diagnostic computed tomography (CT) scan for CRS symptoms in a tertiary care clinic. The study was conducted in 2 phases: (1) using a retrospective review of otolaryngologist\u2010documented symptoms (ODS) in the medical record; and (2) using patient\u2010reported symptoms (PRS) on a prospectively collected customized review of systems form from a separate cohort. A radiographic gold standard differentiated CRS from non\u2010CRS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subjects in the CRS and non\u2010CRS group were matched for age and race and almost universally met symptomatic criteria as defined by the RSTF in both study phases. In both study phases, facial pain, but not facial pressure, was negatively predictive for CRS (<jats:italic>p<\/jats:italic> &lt; 0.05). Similarly, hyposmia was positively predictive, whereas facial pain of a pulsating quality and photophobia were negatively predictive (<jats:italic>p<\/jats:italic> &lt; 0.05), although analysis of PRS was significant only when symptom frequency was considered. Nonetheless, significant overlap exists between the prevalence and frequency of symptoms in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The symptom\u2010based diagnosis of CRS is challenging but symptoms of hyposmia is positively predictive while facial pain, a throbbing quality, headaches and photophobia are negatively predictive and show promise for improving the specificity of CRS diagnosis. Further validation studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21106","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T20:02:11Z","timestamp":1352145731000},"page":"307-314","source":"Crossref","is-referenced-by-count":30,"title":["Identifying clinical symptoms for improving the symptomatic diagnosis of chronic rhinosinusitis"],"prefix":"10.1002","volume":"3","author":[{"given":"Wayne D.","family":"Hsueh","sequence":"first","affiliation":[{"name":"Feinberg School of Medicine Northwestern University  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Conley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine Northwestern University  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haena","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine Northwestern University  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Shintani\u2010Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine Northwestern University  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh K.","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine Northwestern University  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine Northwestern University  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce K.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine Northwestern University  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240301700106"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000224508.59725.19"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770001-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59980223295-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.3006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.06.726"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.04.012"},{"key":"e_1_2_6_9_1","first-page":"9","volume-title":"Cephalalgia","year":"2004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2001.041007646.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.12.007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.00811.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240201600404"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir747"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065898781390208"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752\u2013699X.2012.00281.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32831b9e45"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1212\/WNL.58.9_suppl_6.S3","article-title":"The role of concomitant headache types and non\u2010headache co\u2010morbidities in the underdiagnosis of migraine","volume":"58","author":"Diamond ML","year":"2002","journal-title":"Neurology"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00688.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3172"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900110025004"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900116"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-1983"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino50E2"}],"container-title":["International Forum of Allergy &amp; 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