{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:57:59Z","timestamp":1781650679929,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T00:00:00Z","timestamp":1357776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sarcoidosis is a chronic disease process characterized by non\u2010caseating granulomatous inflammation, usually involving the lower respiratory tract. Given the rarity of rhinologic involvement, the objectives of the present study were (1) to describe clinical features, and (2) to review outcomes of rhinologic surgery for sinonasal sarcoidosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis was performed of patients evaluated at a tertiary care referral center between January 2006 and July 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the 38 patients with sinonasal sarcoidosis was 52 years, with a female:male ratio of 2.8:1. The most common presenting symptoms included nasal obstruction (65.8%), crusting (29.9%), and epistaxis (18.4%). Most frequent endoscopic findings included crusting (55.3%), mucosal thickening (44.7%), and subcutaneous nodules (21%). Computed tomography (CT) imaging demonstrated turbinate or septal nodularity (21%), osteoneogenesis (15.8%), and bone erosion (10.5%). Medical management was typically comprised of saline irrigations (73.3%), topical nasal steroids (68.4%), and oral steroids (63.2%). Refractory sinus symptoms required sinonasal surgery in 4 cases. Overall subjective symptom improvement was noted in 39.5% at mean follow\u2010up of 16.2 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sinonasal involvement was noted in approximately 30% of patients with known sarcoidosis evaluated in the otolaryngology clinic. Patients typically present with nasal obstruction and endoscopic evidence of crusting and mucosal thickening. Medical therapy with irrigations and topical\/oral steroids suffices in majority of patients, with surgery for refractory symptoms being required in a small subset of cases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21142","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T21:47:07Z","timestamp":1357854427000},"page":"567-572","source":"Crossref","is-referenced-by-count":24,"title":["Sinonasal manifestations of sarcoidosis: a single institution experience with 38 cases"],"prefix":"10.1002","volume":"3","author":[{"given":"Mohammad","family":"Aloulah","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Texas Southwestern Medical Center  Dallas TX"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery King Abdulaziz University Hospital, King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Peter","family":"Manes","sequence":"additional","affiliation":[{"name":"Section of Otolaryngology Yale School of Medicine  New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuk Hui","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Texas Southwestern Medical Center  Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine University of Texas Southwestern Medical Center  Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig S.","family":"Glazer","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine University of Texas Southwestern Medical Center  Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Texas Southwestern Medical Center  Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley F.","family":"Marple","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Texas Southwestern Medical Center  Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete S.","family":"Batra","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Texas Southwestern Medical Center  Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.2.ats4-99"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(03)00030-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000147928.06390.db"},{"key":"e_1_2_6_5_1","first-page":"301","article-title":"Vorgesetzte untersuchungen \u00fcber das multiple benign Sarkoid","volume":"73","author":"Boeck C","year":"1905","journal-title":"Scand J Respir Dis"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1983.93.10.1281"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065800782102753"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100093026"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.93.01030269"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065893781976366"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(98)70282-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70421-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100145529"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240101500406"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065801779954157"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000236955.79966.07"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20161"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.31.6.660"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600622"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21142","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T22:05:56Z","timestamp":1696543556000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,10]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1002\/alr.21142"],"URL":"https:\/\/doi.org\/10.1002\/alr.21142","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,10]]}}}