{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T06:15:54Z","timestamp":1696659354879},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T00:00:00Z","timestamp":1363737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study compares the ability of mucosal brush biopsy (MBB) from 2 separate locations in the oral cavity to detect peanut\u2010specific immunoglobulin E (IgE) in patients who report adverse oral cavity reactions when ingesting peanuts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty patients who reported a history of oral cavity itching or swelling when ingesting peanuts underwent either MBB of the dorsal tongue (n = 10) or the vestibule (n = 10). Serum testing for total and peanut\u2010specific IgE, using standard immunofluorescent assay, was obtained for all patients. Total and specific IgE for each location were compared. Additionally, the correlation between MBB and peanut\u2010specific IgE on serum was determined using Fisher's exact probability testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peanut\u2010specific IgE was detected in 3 of 10 (30%) MBB specimens from the dorsal tongue and in 10 of 10 (100%) MBB specimens from the vestibule. The mean peanut\u2010specific IgE on MBB (kU\/L) in the dorsal tongue group was 0.03 vs 0.17 in the vestibule group (<jats:italic>p<\/jats:italic> = 0.0002). No significant association was noted for peanut\u2010specific IgE between MBB and serum testing (<jats:italic>p<\/jats:italic> = 1.0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates for the first time that peanut\u2010specific IgE can be detected using MBB in the oral cavity of patients who are symptomatic when consuming peanuts. The vestibule was a superior location compared to the dorsal tongue for oral cavity MBB, correlating very well with self\u2010reported symptoms. Peanut\u2010specific IgE on MBB overall did not correlate well with serum testing for peanut\u2010specific IgE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21164","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T18:37:54Z","timestamp":1363804674000},"page":"636-641","source":"Crossref","is-referenced-by-count":8,"title":["Mucosal brush biopsy of the oral cavity to detect local, peanut\u2010specific immunoglobulin E"],"prefix":"10.1002","volume":"3","author":[{"given":"William R.","family":"Reisacher","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Weill Cornell Medical College  New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin C.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Weill Cornell Medical College  New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1210"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0204"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1016\/j.jaci.2009.08.028","article-title":"Food allergy","volume":"125","author":"Sicherer SH","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00556.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70392-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/j.1398-9995.2004.00466.x","article-title":"Standardization of food challenges in patients with immediate reactions to foods: position paper from the European Academy of Allergology and Clinical Immunology","volume":"59","author":"Bindslev\u2010Jensen C","year":"2004","journal-title":"Allergy"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.35.3.357"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03380130091034"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000057776"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.03.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20103"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2009.11.007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2012.01315.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0800871"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01611.x"},{"key":"e_1_2_7_17_1","unstructured":"VassarStats: Website for Statistical Computation.http:\/\/www.vassarstats.net. 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