{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:26:07Z","timestamp":1763036767014},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T00:00:00Z","timestamp":1367452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recent research suggest that B and plasma cells may play an important role in the pathogenesis of chronic rhinosinusitis with nasal polyposis (CRSwNP). The purpose of this study was to subcharacterize the B cell response in the sinus mucosa of control and CRS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Representative tissue samples and peripheral blood samples were obtained from controls, CRS without nasal polyps (CRSsNP) and CRSwNP. Using single\u2010cell suspension flow cytometry these samples were analyzed for overall and stage\u2010specific B and plasma cell percentages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both atopic and nonatopic CRSwNP patients showed an increase in local numbers of naive, active, and memory B cells compared to controls. CRSsNP patients only showed local elevations of naive B cells. Plasma cells were only significantly elevated in the sinus tissue of atopic CRSwNP patients. These local tissue increases did not correlate with increased numbers of circulating B cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides further evidence of an important role of B cells in CRSwNP patients. The local increase appears to be independent of a systemic response.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21173","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T21:22:55Z","timestamp":1367529775000},"page":"621-629","source":"Crossref","is-referenced-by-count":19,"title":["Characterization of B\u2010cell subpopulations in patients with chronic rhinosinusitis"],"prefix":"10.1002","volume":"3","author":[{"given":"Alkis J.","family":"Psaltis","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney J.","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston SC"},{"name":"Ralph H. Johnson VA Medical Center  Charleston SC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Yawn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oswaldo","family":"Henriquez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston SC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer K.","family":"Mulligan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical University of South Carolina  Charleston SC"},{"name":"Ralph H. Johnson VA Medical Center  Charleston SC"},{"name":"Department of Pediatrics Medical University of South Carolina  Charleston SC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,2]]},"reference":[{"issue":"249","key":"e_1_2_6_2_1","first-page":"1","article-title":"Summary health statistics for U.S. adults: National Health Interview Survey, 2009","volume":"10","author":"Pleis JR","year":"2010","journal-title":"Vital Health Stat"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.09.067"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3356"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01132.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01225.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.03.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02838.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3386"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2009.01931.x"},{"key":"e_1_2_6_11_1","first-page":"380","article-title":"Immunologic factors in patients with chronic polypoid sinusitis","volume":"18","author":"Nikakhlagh S","year":"2009","journal-title":"Niger J Med"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.08.037"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4161\/hv.6.8.12020"},{"key":"e_1_2_6_14_1","first-page":"1447","article-title":"Paracetamol (acetaminophen) poisoning","author":"Buckley N","year":"2002","journal-title":"Clin Evid"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1607-551X(09)70046-4"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eum290"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323903"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05118-11"},{"key":"e_1_2_6_19_1","volume-title":"Current Protocols in Cytometry","author":"Rawstron A","year":"2001"},{"key":"e_1_2_6_20_1","first-page":"1182","volume-title":"Leucocyte Typing IV: White Cell Differentiation Antigens","author":"Knapp W","year":"1989"},{"key":"e_1_2_6_21_1","volume-title":"Current Protocols in Immunology","author":"Heine G","year":"2001"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.018689"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12008"},{"key":"e_1_2_6_24_1","volume-title":"The Leucocyte Antigen FactsBook","author":"Barclay AN","year":"1997"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21173","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T14:45:21Z","timestamp":1696603521000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,2]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1002\/alr.21173"],"URL":"https:\/\/doi.org\/10.1002\/alr.21173","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,2]]}}}