{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:40:58Z","timestamp":1787866858683,"version":"build-2784847793"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T00:00:00Z","timestamp":1369267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intranasal and oral corticosteroids are widely used in the management of chronic rhinosinusitis with nasal polyps (CRSwNP). Higher\u2010dose topical nasal steroids (HDTNS) such as budesonide irrigations are increasingly used for long\u2010term maintenance in these patients. Oral steroids have the potential to cause increased intraocular pressure (IOP) and glaucoma. It is unclear whether HDTNS have the same potential. The objective of this study was to determine the effect of intranasal budesonide irrigations on IOP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two groups of patients with CRSwNP treated with budesonide irrigations were prospectively enrolled. Patients with history of elevated IOP or glaucoma were excluded. Patients in group 1 had been using budesonide for at least 1 month and had IOP measured once at the time of enrollment. Group 2 consisted of patients who were placed on budesonide at the time of enrollment and had IOP measured both before and after at least 4 weeks of therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten patients in group 1 and 8 patients in group 2 completed the study. In group 1, the average duration of therapy at enrollment was 6.3 months (1\u201322 months). Only 1 patient had a single eye pressure above 21 mmHg. None of the patients in group 2 had a significant change in IOP or IOP over 21 mmHg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intranasal budesonide irrigations given for a period of at least 1 month do not appear to increase IOP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.21180","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T15:00:26Z","timestamp":1369321226000},"page":"704-707","source":"Crossref","is-referenced-by-count":36,"title":["Effect of intranasal budesonide irrigations on intraocular pressure"],"prefix":"10.1002","volume":"3","author":[{"given":"Kristin A.","family":"Seiberling","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Loma Linda University Medical Center  Loma Linda CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis F.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Loma Linda University Medical Center  Loma Linda CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Nyirady","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Loma Linda University Medical Center  Loma Linda CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Loma Linda University Medical Center  Loma Linda CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Loma Linda University Medical Center  Loma Linda CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2110047"},{"key":"e_1_2_6_3_1","first-page":"97","article-title":"EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists","volume":"45","author":"Fokkens W","year":"2007","journal-title":"Rhinology"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198428020-00002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.03.009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000205218.37514.0f"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2009.07.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.1998.00096.x"},{"key":"e_1_2_6_9_1","first-page":"1","article-title":"Local and systemic safety of intranasal corticosteroids","volume":"22","author":"Sastre J","year":"2012","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200306000-00013"},{"key":"e_1_2_6_11_1","first-page":"CD006549","article-title":"Topical steroids for nasal polyps","volume":"12","author":"Kalish L","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_12_1","first-page":"100","article-title":"Effect of Pulmicort Respule on rehabilitation after functional endoscopic sinus surgery","volume":"21","author":"Yu CC","year":"2007","journal-title":"Acta Chimi Sin"},{"key":"e_1_2_6_13_1","first-page":"942","article-title":"The effect of Pulmicort on pediatric chronic sinusitis","volume":"21","author":"Qiao L","year":"2007","journal-title":"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2008.555"},{"key":"e_1_2_6_15_1","first-page":"821","article-title":"Safety of budesonide in saline sinonasal irrigations in the management of chronic rhinosinusitis with polyposis: lack of significant adrenal suppression","volume":"37","author":"Bhalla RK","year":"2008","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3418"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540330044033"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21180","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21180","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:21:49Z","timestamp":1696551709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,23]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1002\/alr.21180"],"URL":"https:\/\/doi.org\/10.1002\/alr.21180","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718013043.793485454","asserted-by":"object"}]},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,23]]}}}