{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:32:04Z","timestamp":1790235124698,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T00:00:00Z","timestamp":1370390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis (CRS) is a common disease with a significant impact on health\u2010related quality of life (QOL) of the patient. Histologic inflammatory markers in CRS are an important marker in determining the severity of the disease. In this study, we evaluated the association of histopathologic parameters with QOL questionnaires in patients with CRS with nasal polyposis after endoscopic sinus surgery (ESS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 57 patients were included in this study. Preoperative patient characteristics, clinical findings, and computed tomography scores were recorded. Two QOL measures, the Rhinosinusitis Disability Index (RSDI) and Short Form\u201036 General Health Survey (SF\u201036) were analyzed preoperatively and postoperatively. Sinus mucosal specimens were collected at the time of surgery. Presence of the inflammation was evaluated with cellular (eosinophils, neutrophils, lymphocytes, mast cells, macrophages), epithelial (basement membrane thickness [BMT], goblet cell) and stromal markers (subepithelial edema). The histopathological findings were compared statistically with the QOL measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In comparison of the absolute change of the RSDI and SF\u201036 scores with mucosal eosinophilia, patients with eosinophilia showed significantly less improvement only in the SF\u201036 physical functioning subscale (p\u00a0= 0.004). There was a statistically significant relationship between BMT and RSDI total (p\u00a0= 0.042), emotional scores (p\u00a0= 0.003), SF\u201036 general health (<jats:italic>p<\/jats:italic>\u00a0= 0.032), SF\u201036 physical function (<jats:italic>p<\/jats:italic>\u00a0= 0.007), SF\u201036 bodily pain (<jats:italic>p<\/jats:italic>\u00a0= 0.044), and SF\u201036 mental health (<jats:italic>p<\/jats:italic>\u00a0= 0.022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For most patients QOL significantly improved after surgery. Mucosal eosinophilia did not correlate with the absolute change of the RSDI. However, thickening of basal membrane adversely affects symptoms of the patients and correlates with the disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21183","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T16:17:58Z","timestamp":1370449078000},"page":"828-833","source":"Crossref","is-referenced-by-count":29,"title":["Histopathologic parameters in chronic rhinosinusitis with nasal polyposis: impact on quality of life outcomes"],"prefix":"10.1002","volume":"3","author":[{"given":"Fatih Kemal","family":"Soy","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Department Katip Celebi University Ataturk Training and Research Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ercan","family":"Pinar","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department Katip Celebi University Ataturk Training and Research Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulkadir","family":"Imre","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department Katip Celebi University Ataturk Training and Research Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caglar","family":"Calli","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Department Katip Celebi University Ataturk Training and Research Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin","family":"Calli","sequence":"additional","affiliation":[{"name":"Pathology Department Katip Celebi University Ataturk Training and Research Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semih","family":"Oncel","sequence":"additional","affiliation":[{"name":"Vocational School of Health Services Dokuz Eylul University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240301700106"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2005.08.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000147922.12228.1f"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000182825.82910.80"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.3.329"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900518"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199504000-00010"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900110025004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.10.005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/hn.2003.v128.amhn0312811"},{"key":"e_1_2_6_13_1","first-page":"183","article-title":"Staging in rhinosinusitis","volume":"31","author":"Lund VJ","year":"1993","journal-title":"Rhinology"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770005-6"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00107-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.03.001"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2010.34"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.2978"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000224575.12945.90"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.3005"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.10.009"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31815d74bb"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.06.085"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.12.026"}],"container-title":["International Forum of Allergy &amp; 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