{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:28:20Z","timestamp":1791804500267,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T00:00:00Z","timestamp":1371427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Nasal steroids play an important role in the postoperative management of patients with chronic rhinosinusitis (CRS). However, commercially available nasal steroid sprays may not deliver adequate amounts of medication to the entire postoperative sinus cavity. The off\u2010label use of budesonide nasal irrigation (BNI) theoretically solves this problem by delivering concentrated steroid solution through a high\u2010pressure, high\u2010volume system. Several studies have attested to the safety of BNI, but there are very few reports of its efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective review of prospectively\u2010collected data. We identified 60 patients who were prescribed BNI postoperatively, but had a lapse in therapy for 1 month or longer. The 20\u2010item Sinonasal Outcomes Test (SNOT\u201020) and Lund\u2010Kennedy endoscopy scores while the patients were using BNI were compared with scores from the same patients while they were not using BNI. Student paired <jats:italic>t<\/jats:italic> test was used for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients had eosinophilic chronic rhinosinusitis (eCRS) with polyps (eCRSwNP), 13 had allergic fungal sinusitis (AFS), 13 had Samter's triad (ST), and 4 had eosinophilic chronic rhinosinusitis without polyps (eCRSsNP). Mean follow\u2010up time was 25 months (range, 2\u201389 months). Overall, SNOT\u201020 scores were significantly lower with BNI (<jats:italic>p<\/jats:italic> &lt; 0.05). On subgroup analysis, SNOT\u201020 scores were significantly improved with BNI for patients with eCRS and Samter's triad (<jats:italic>p<\/jats:italic> = 0.04, 0.03). Endoscopy scores were significantly improved only in the eCRS group (<jats:italic>p<\/jats:italic> = 0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The addition of BNI is beneficial in the postoperative management of patients with CRS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21189","type":"journal-article","created":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T16:32:59Z","timestamp":1371486779000},"page":"708-711","source":"Crossref","is-referenced-by-count":65,"title":["Budesonide nasal irrigations in the postoperative management of chronic rhinosinusitis"],"prefix":"10.1002","volume":"3","author":[{"given":"David W.","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical College of Georgia Georgia Regents University  Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios A.","family":"Lachanas","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical College of Georgia Georgia Regents University  Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Segel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical College of Georgia Georgia Regents University  Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stilianos E.","family":"Kountakis","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Medical College of Georgia Georgia Regents University  Augusta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.121022"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510410s02"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61955-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065897781446658"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.92.4.594"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.4.447"},{"key":"e_1_2_6_8_1","first-page":"57","article-title":"Efficacy and tolerability of budesonide aqueous nasal spray in chronic rhinosinusitis patients","volume":"42","author":"Lund VJ","year":"2004","journal-title":"Rhinology"},{"key":"e_1_2_6_9_1","first-page":"2","article-title":"Functional endoscopic sinus surgery: 5 year follow up and results of a prospective, randomised, stratified, double\u2010blind, placebo controlled study of postoperative fluticasone propionate aqueous nasal spray","volume":"43","author":"Rowe\u2010Jones JM","year":"2005","journal-title":"Rhinology"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2904"},{"key":"e_1_2_6_12_1","first-page":"183","article-title":"Mometasone furoate gel: a novel in\u2010office treatment of recalcitrant postoperative chronic rhinosinusitis","volume":"41","author":"Alava I","year":"2012","journal-title":"J Otolaryngol Head Neck Surg."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.03.009"},{"key":"e_1_2_6_14_1","first-page":"821","article-title":"Safety of budesonide in saline sinonasal irrigations in the management of chronic rhinosinusitis with polyposis: lack of significant adrenal suppression","volume":"37","author":"Bhalla RK","year":"2008","journal-title":"J Otolaryngol Head Neck Surg."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2008.555"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3418"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22396"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21047"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000147917.43615.c0"}],"container-title":["International Forum of Allergy &amp; 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