{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T10:27:49Z","timestamp":1759228069501},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Intranasal medication delivery for allergic rhinitis (AR) is considered a mainstay of therapy but is hampered by poor compliance. Among reasons given are unpleasant sensations associated with spray penetration into the pharynx. Our objective was to study a novel method of particle delivery to the nose that would abrogate these issues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a double\u2010blind, randomized study. Subjects who met study criteria underwent intranasal particle delivery using a novel device (Trivair Nasal Deposition System; Trimel Pharmaceuticals, Toronto, Canada) that delivered anhydrous lactose particles into the nose via a transoral air puff (thus elevating soft palate and blocking the nasopharynx). Subjects had nostrils randomized into 4 groups (particle sizes 5 \u03bcm and 50 \u03bcm \u00d7 doses 12.5 mg and 25 mg). Particle deposition was assessed at 1 minute, 10 minutes, and 30 minutes on the inferior turbinate, middle turbinate, and nasopharynx, respectively, using high\u2010definition endoscopic photography. Each image was compared using an expert blinded 2\u2010person panel for percentage particles remaining. Nonparametric data was assessed using the Wilcoxon signed\u2010rank test via Strata software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve nostrils in total met study criteria. The results showed no difference in effectiveness of nasal particle retention between the groups based on particle size or dose. No particles entered the nasopharynx or oropharynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides proof\u2010of\u2010principle data that the Trivair Nasal Deposition System is effective at retaining medication in the nose without pharyngeal penetration. Larger studies on this device are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21199","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T09:03:05Z","timestamp":1374224585000},"page":"905-910","source":"Crossref","is-referenced-by-count":3,"title":["A novel device for delivery of intranasal particulate medication: a pilot study"],"prefix":"10.1002","volume":"3","author":[{"given":"Sammy","family":"Khalili","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Tkachenko","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Rotenberg","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.00237.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2007.28.2992"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61957-6"},{"key":"e_1_2_6_5_1","first-page":"17","article-title":"Particle deposition efficiency of therapeutic aerosols in the human maxillary sinus","volume":"27","author":"Hyo N","year":"1989","journal-title":"Rhinology"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/194589240401800101","article-title":"Particle deposition of therapeutic aerosols in the nose and paranasal sinuses after transnasal sinus surgery: a cast model study","volume":"18","author":"Saijo R","year":"2004","journal-title":"Am J Rhinol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.129738"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3192"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000199741.08517.99"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S25199"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/jam.2004.17.249"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21199","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T21:19:19Z","timestamp":1696540759000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,18]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1002\/alr.21199"],"URL":"https:\/\/doi.org\/10.1002\/alr.21199","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,18]]}}}