{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:15:38Z","timestamp":1781010938154,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To critically review the current literature regarding aspirin desensitization treatment for nasal polyposis in patients with Aspirin\u2010Exacerbated Respiratory Disease (AERD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Systematic review of the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All English literature published between January 1995 and February 2013 reporting specifically nasal outcomes following aspirin desensitization in AERD patients were eligible for inclusion. Exclusion criteria were non\u2010investigative, non\u2010human, and ex\u2010vivo studies. Studies were categorized by level of evidence and evaluated for quality using the Downs and Black scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 614 citations were retrieved and eleven studies met the criteria for analysis. Outcome measurements included self\u2010reported symptom scores, amount of corticosteroid use, rate of revision surgery, and quantitative measurements such as rhinomanometry. Overall, most studies reported a significant improvement in symptom scores, decrease in corticosteroid use, and decrease in revision surgery. A few studies showed promising results with quantitative outcomes. However, most studies were of Level 2 evidence with small samples sizes. Rates of adverse events ranged from 12.5% to 23%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Unlike traditional treatments for nasal polyposis, aspirin desensitization targets AERD etiology rather than phenotype and can be an effective therapeutic option. While the current literature shows encouraging results, additional studies are needed to better define clinical benefits.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21202","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T13:33:08Z","timestamp":1373981588000},"page":"915-920","source":"Crossref","is-referenced-by-count":34,"title":["Aspirin desensitization for aspirin\u2010exacerbated respiratory disease (Samter's Triad): a systematic review of the literature"],"prefix":"10.1002","volume":"3","author":[{"given":"Jason J.","family":"Xu","sequence":"first","affiliation":[{"name":"Schulich School of Medicine &amp; Dentistry University of Western Ontario  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh","family":"Sowerby","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Western Ontario  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W.","family":"Rotenberg","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Western Ontario  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2011.3.1.3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1325618"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22396"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941112000304"},{"issue":"23","key":"e_1_2_6_6_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","volume":"2012","author":"Fokkens WJ","journal-title":"Rhinology Supplement"},{"key":"e_1_2_6_7_1","first-page":"S1","article-title":"Clinical practice guideline: Adult sinusitis","volume":"137","author":"Rosenfeld RM","year":"2007","journal-title":"Otolaryngology\u2013Head and Neck Surgery"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.52.6.377"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61803-0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.7"},{"issue":"1","key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4193\/Rhino09.113","article-title":"Aspirin desensitization for ASA triad patients\u2013prospective study of the rhinologist's perspective","volume":"49","author":"Forer B","year":"2011","journal-title":"Rhinology"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.3.316"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2048-x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.036"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.011"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01658.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70123-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215107000515"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000166702.38850.1B"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.suppl_2.S75"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T21:19:24Z","timestamp":1696540764000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,16]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1002\/alr.21202"],"URL":"https:\/\/doi.org\/10.1002\/alr.21202","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,16]]}}}