{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:45:26Z","timestamp":1783975526531,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T00:00:00Z","timestamp":1374537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Bronchiectasis is an uncommon disease of the lower airways characterized by bronchial wall destruction and permanent bronchiolar dilation. Several etiologic categories exist, and patients with bronchiectasis often complain of symptoms suggestive of chronic rhinosinusitis (CRS). The present study investigates the association between bronchiectasis and CRS using radiologic and bacteriologic data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective chart review from a tertiary care respiratory hospital was performed. Sinus computed tomography (CT) scans were examined for extent of disease and relationship to pulmonary disease severity. Statistical analysis was performed with Student <jats:italic>t<\/jats:italic> test and linear regression. Upper and lower airway cultures from patients with both bronchiectasis and CRS were compared using the chance adjusted agreement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with bronchiectasis were found to have a significantly higher Lund\u2010Mackay score when compared to patients with allergic rhinitis (<jats:italic>p<\/jats:italic> = 0.047). Lund\u2010Mackay CT score did not correlate with forced expiratory volume in 1 second (FEV<jats:sub>1<\/jats:sub>) and FEV<jats:sub>1<\/jats:sub>:forced vital capacity (FVC), or presence of <jats:italic>Pseudomonas aeruginosa<\/jats:italic>. Correlation of upper and lower airway bacterial cultures in patients with both bronchiectasis and CRS was noted (kappa = 0.294, <jats:italic>p<\/jats:italic> = 0.004), particularly when <jats:italic>P. aeruginosa<\/jats:italic> was present (kappa = 0.49, <jats:italic>p<\/jats:italic> &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current study suggests that the upper and lower airways may be linked in CRS and bronchiectasis from both an objective radiologic standpoint and a bacteriologic perspective. This finding carries implications for disease pathogenesis, clinical care, and future research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21204","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T15:08:27Z","timestamp":1374678507000},"page":"921-927","source":"Crossref","is-referenced-by-count":26,"title":["Upper and lower airways associations in patients with chronic rhinosinusitis and bronchiectasis"],"prefix":"10.1002","volume":"3","author":[{"given":"Vijay R.","family":"Ramakrishnan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Colorado  Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey R.","family":"Ferril","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Colorado  Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California Los Angeles  Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trudi","family":"Woodson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kaiser Permanente  Denver CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler J.","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Colorado  Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd T.","family":"Kingdom","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Colorado  Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2010.10.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2006.01219.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.023"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2007.11.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200310000-00008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328010d0db"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2012.26.3762"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e3282f4efc9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2012.10.009"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00977665"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200101000-00002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215107009140"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198401053100102"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.01.072"},{"key":"e_1_2_7_16_1","first-page":"379","article-title":"Immunologic aspects of chronic sinusitis","volume":"20","author":"Lund VJ","year":"1991","journal-title":"J Otolaryngol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90176-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.03.012"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01892.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770005-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.07.021"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.06.726"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.9906120"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900020077011"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2907"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3284"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811407279"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.1.15"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0490"}],"container-title":["International Forum of Allergy &amp; 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