{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:25:47Z","timestamp":1785464747415,"version":"3.56.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"American Academy of Otolaryngic Allergy Research in Otolaryngology and Allergy Development (ROAD) Scholarship Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The diagnosis of inhalant allergies involves a medical history, physical exam, and allergen sensitivity testing; allergen sensitivity can be assessed by a specific immunoglobulin E (IgE) screen for inhalant allergens. Some patients with clinical suspicion for inhalant allergies have a negative specific IgE screen, but high total IgE. We theorize that elevated total IgE may indicate a false\u2010negative screen caused by \u201cmissed allergens\u201d not initially identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Study patients with a negative allergy screen and elevated IgE (&gt;116 kU\/L) were identified (n = 26). Control patients (n = 26) were defined as having a negative screen and an IgE &lt;2.95 kU\/L. Both groups were tested with an expanded specific IgE panel and completed a questionnaire about other causes of elevated IgE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The expanded panel was positive for inhalant allergens in 4 study patients (15%) and 0 control patients (<jats:italic>p<\/jats:italic> = 0.037). Within the study patients, 50% had asthma and 76.9% had chronic sinusitis. Only 2 control patients had asthma (11.5%), <jats:italic>p<\/jats:italic> = 0.003; 4 (19.2%) reported chronic sinusitis, <jats:italic>p<\/jats:italic> &lt; 0.0001. Food allergen sensitivity was identified in 5 study patients and 1 control, <jats:italic>p<\/jats:italic> = 0.083.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This pilot study evaluated patients clinically suspected of allergy with a negative inhalant IgE screen. Those with a high total IgE were more likely to have a missed inhalant allergen on expanded testing, as well as asthma and chronic sinusitis, compared to those with a low total IgE. Further investigation of \u201cmissed antigen\u201d and the role of chronic respiratory inflammatory disease in patients with elevated total IgE is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21207","type":"journal-article","created":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T19:34:00Z","timestamp":1377200040000},"page":"782-787","source":"Crossref","is-referenced-by-count":8,"title":["Total serum immunoglobulin E as a marker for missed antigens on in vitro allergy screening"],"prefix":"10.1002","volume":"3","author":[{"given":"Jeanne L.","family":"Hatcher","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Wake Forest School of Medicine  Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel D.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Wilson Ear Nose and Throat  Wilson NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Whit","family":"Mims","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Wake Forest School of Medicine  Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2011.03.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1982.00790600025007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770206-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(96)70146-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)30792-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.3.e8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16d07.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000094897"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0546(05)73247-X"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.017681"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60015-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.05.048"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.03.018"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.032"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21207","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T06:27:44Z","timestamp":1696573664000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,22]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1002\/alr.21207"],"URL":"https:\/\/doi.org\/10.1002\/alr.21207","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,22]]}}}