{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:25:56Z","timestamp":1782386756620,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T00:00:00Z","timestamp":1383523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sinonasal melanoma (SNM) is a rare malignancy that commonly presents at an advanced age and has a slight male predominance. Local recurrence has been implicated as a major reason for treatment failure, and there are poor reported 5\u2010year survival rates. We analyzed the impact of specific location within the sinonasal region on the survival of this rare malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The U.S. National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry was used to extract data on SNM between 1973 and 2009. Survival trends and hazard ratios (HRs) were calculated to compare the prognostic implications of involvement of varying areas of the sinonasal tract.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 567 cases were identified. Females constituted 56.44% patient. Disease\u2010specific survival (DSS) at 5 years was 36.66% for patients diagnosed with nasal cavity disease, 23.80% for patients with maxillary sinus tumors, and 18.20% for patients with ethmoid sinus disease. Patients showing evidence of overlapping sinus involvement had approximate 1\u2010year survival of 54.45% and none survived beyond 49 months. HRs for maxillary sinus, ethmoid sinus, and overlapping sinus disease were 1.34, 1.60, and 2.30, respectively. All DSSs and HRs were statistically significant (<jats:italic>p<\/jats:italic> &lt; 0.05). There was a higher proportion of earlier\u2010stage disease in the nasal cavity compared to the most common paranasal sinus region (<jats:italic>p<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prognosis in SNM is dependent on the anatomic subsite. Paranasal sinus involvement indicates a poorer prognosis when compared to nasal cavity disease. Patients presenting with overlapping sinus involvement have the poorest prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21243","type":"journal-article","created":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T17:22:44Z","timestamp":1383585764000},"page":"151-155","source":"Crossref","is-referenced-by-count":44,"title":["Sinonasal melanoma: survival and prognostic implications based on site of involvement"],"prefix":"10.1002","volume":"4","author":[{"given":"Mohemmed N.","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mount Sinai School of Medicine  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek V.","family":"Kanumuri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milap D.","family":"Raikundalia","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Govindaraj","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mount Sinai School of Medicine  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soly","family":"Baredes","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Anderson","family":"Eloy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"},{"name":"Center for Skull Base and Pituitary Surgery Neurological Institute of New Jersey Rutgers New Jersey Medical School  Newark NJ"},{"name":"Department of Neurological Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23625"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-0067"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3181ee8dcb"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.01.014"},{"key":"e_1_2_6_6_1","first-page":"739","article-title":"Primary mucosal melanomas: a comprehensive review","volume":"5","author":"Mihajlovic M","year":"2012","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896911417970"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e32834b58cf"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3283374d31"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23079"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin12.075"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31828d73bf"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-42-500-561"},{"key":"e_1_2_6_14_1","first-page":"201","article-title":"[Analysis of the late curative effect of 432 cases with advanced squamous cell carcinoma of the maxillary sinus]","volume":"34","author":"Ren B","year":"1999","journal-title":"Zhonghua er bi yan hou ke za zhi"},{"key":"e_1_2_6_15_1","volume-title":"American Joint Committee on Cancer","author":"Edge SB","year":"2010"},{"key":"e_1_2_6_16_1","volume-title":"VassarStats: web site for statistical computation","author":"Lowry R","year":"1998"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21925"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24976"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.12.013"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1980.00790350027008"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21340"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1301400"}],"container-title":["International Forum of Allergy &amp; 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