{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:31:01Z","timestamp":1788827461258,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T00:00:00Z","timestamp":1388620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The relationship between allergy and chronic rhinosinusitis (CRS) remains ill\u2010defined and controversial. The association between the 2 is unclear, making an evidence\u2010based decision of whether to evaluate and treat allergies in CRS patients difficult. The purposes of this systematic review are to (1) examine the relationship between allergy and CRS without nasal polyps (CRSsNP), (2) examine the same for allergy and CRS with nasal polyps (CRSwNP), and (3) recommend evaluation and treatment based on the evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A structured literature search was performed to identify articles examining the link between allergy and CRSsNP and CRSwNP. Pertinent articles were examined for evidence for an association between allergy and CRSsNP and\/or CRSwNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 24 articles were found that met the inclusion criteria; 18 articles examined the relationship between allergy and CRSwNP, with 10 articles showing an association, 7 articles showing no association, and 1 article showing a possible association. Nine articles examined the relationship between allergy and CRSsNP, with 4 articles showing an association and 5 articles showing no association. Four studies directly compared the role of allergy in CRSwNP and CRSsNP, and, again, the results were mixed. No articles examined the outcomes of CRSsNP or CRSwNP following allergy treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The role of allergy in CRSwNP and CRSsNP continues to be controversial, with the level of evidence poor. Based on the available data, the recommendation is that allergy testing and treatment are an <jats:italic>option<\/jats:italic> in CRSwNP and CRSsNP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21258","type":"journal-article","created":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T18:16:41Z","timestamp":1388686601000},"page":"93-103","source":"Crossref","is-referenced-by-count":127,"title":["The association between allergy and chronic rhinosinusitis with and without nasal polyps: an evidence\u2010based review with recommendations"],"prefix":"10.1002","volume":"4","author":[{"given":"Kevin F.","family":"Wilson","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Christopher","family":"McMains","sequence":"additional","affiliation":[{"name":"Department of Surgery Uniformed Services University of Health Sciences  Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.05.017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.05.072"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.06.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1991.tb00537.x"},{"issue":"5","key":"e_1_2_7_6_1","first-page":"S17","article-title":"Rhinosinusitis: developing guidance for clinical trials","volume":"118","author":"Meltzer EO","year":"2006","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.01964.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01132.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2500\/108854196778662264"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20025"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31817d01b8"},{"key":"e_1_2_7_12_1","first-page":"110","article-title":"Allergenic profile of nasal polyposis","volume":"19","author":"Mu\u00f1oz del Castillo F","year":"2009","journal-title":"J Investig Allerg Clin Immunol"},{"key":"e_1_2_7_13_1","first-page":"13","article-title":"Role of allergy in nasal polyps of Thai patients","volume":"17","author":"Pumhirun P","year":"1999","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)90198-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63299-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.07.005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(00)70259-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2011.25.3686"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.07.013"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.3062"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941212100909"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480500504226"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480701387165"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(94)70068-0"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3284"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065801781329365"},{"key":"e_1_2_7_27_1","first-page":"141","article-title":"Role of allergy in the therapeutic response of nasal polyps","volume":"20","author":"Kirtsreesakul V","year":"2002","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00813.x"},{"key":"e_1_2_7_29_1","first-page":"204","article-title":"The relationship between allergy and rhinosinusitis","volume":"46","author":"Kirtsreesakul V","year":"2008","journal-title":"Rhinology"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.02.010"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02530.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2907"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60829-0"}],"container-title":["International Forum of Allergy &amp; 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