{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:43:13Z","timestamp":1788410593789,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T00:00:00Z","timestamp":1389312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases (NIAID)","doi-asserted-by":"crossref","award":["K24 AI080942\/AI\/NIAID NIH HHS\/United States"],"award-info":[{"award-number":["K24 AI080942\/AI\/NIAID NIH HHS\/United States"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with diabetes mellitus (DM) are known to be prone to infection. However, the association between diabetes and chronic rhinosinusitis (CRS) has not been well studied. We sought to determine the effects of DM on CRS culture results and quality of life (QOL) after functional endoscopic sinus surgery (FESS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study. Adult CRS patients undergoing FESS were recruited from October 1, 2007 to December 31, 2011. Patient demographics, comorbidities, medication use, and Lund\u2010Mackay CT scores were collected prior to FESS. Intraoperative culture was obtained. Preoperative and 1\u2010month, 3\u2010month, and 6\u2010month postoperative QOL was measured by scores on the 22\u2010item Sinonasal Outcome Test (SNOT\u201022). A mixed effects model was performed for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 376 CRS patients included, 19 patients (5.05%) had DM. Compared to non\u2010DM patients, DM patients were significantly more likely to have\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      (26.32% vs 7.56%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0= 0.004) and Gram\u2010negative rods (26.32% vs 8.96%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0= 0.013), but there was no significant difference in the prevalence of\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      ; DM patients were also significantly more likely to have nasal polyps and gastroesophageal reflux disease. Additionally, DM patients had significantly less improvement of postoperative SNOT\u201022 scores from baseline to 6\u2010month follow\u2010up than non\u2010DM patients (adjusted mean = 11.14, 95% CI (0.14, 22.15),\n                      <jats:italic>p<\/jats:italic>\n                      = 0.047) after adjusting for all the other risk factors for CRS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DM patients may be prone to Gram\u2010negative bacterial sinus infections, and have significantly worse short\u2010term postoperative QOL. Special postoperative care may need to be considered in CRS patients with DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.21269","type":"journal-article","created":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T14:05:25Z","timestamp":1389362725000},"page":"315-320","source":"Crossref","is-referenced-by-count":59,"title":["The effect of diabetes mellitus on chronic rhinosinusitis and sinus surgery outcome"],"prefix":"10.1002","volume":"4","author":[{"given":"Zi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Epidemiology Center for Clinical Epidemiology and Biostatistics Perelman School of Medicine University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithin D.","family":"Adappa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Perelman School of Medicine University of Pennsylvania  Philadelphia 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