{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:00:42Z","timestamp":1783605642533,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T00:00:00Z","timestamp":1389312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The objective of this work was to determine if specific chronic rhinosinusitis with nasal polyps (CRSwNP) populations are at risk for vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      (VD\n                      <jats:sub>3<\/jats:sub>\n                      ) deficiency and if VD\n                      <jats:sub>3<\/jats:sub>\n                      levels correlate with radiographic measures of disease severity or eosinophilia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study was a retrospective review of an academic rhinology practice. CRSwNP patients who had VD\n                      <jats:sub>3<\/jats:sub>\n                      levels and CT scan within 6 months of each other were included. CT scans were graded using Lund\u2010Mackay scoring (LMS) and peripheral eosinophil counts were measured. Demographic data including race, gender, age, body mass index, atopic status, and presence of asthma were collected. CRSwNP was subdivided into allergic fungal rhinosinusitis (AFRS), aspirin\u2010exacerbated respiratory disease (AERD), and other CRSwNP. Multivariate analysis was performed to examine correlations and control for confounding factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Insufficient VD\n                      <jats:sub>3<\/jats:sub>\n                      levels were found in 55% of all CRSwNP patients. VD\n                      <jats:sub>3<\/jats:sub>\n                      correlated with African American race because nearly 80% of all African Americans had insufficient VD\n                      <jats:sub>3<\/jats:sub>\n                      levels. Lower VD\n                      <jats:sub>3<\/jats:sub>\n                      levels also correlated with more severe mucosal disease on CT scans as measured by LMS. There was no correlation between VD\n                      <jats:sub>3<\/jats:sub>\n                      levels and age, gender, body mass index, atopy, asthma, or CRSwNP subtype.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      VD\n                      <jats:sub>3<\/jats:sub>\n                      insufficiency\/deficiency is common in CRSwNP patients, especially those of African American race. Lower levels of VD\n                      <jats:sub>3<\/jats:sub>\n                      are associated with worse LMS on CT. The role of VD\n                      <jats:sub>3<\/jats:sub>\n                      in CRSwNP warrants further investigation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.21274","type":"journal-article","created":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T14:05:36Z","timestamp":1389362736000},"page":"196-199","source":"Crossref","is-referenced-by-count":47,"title":["Impact of vitamin D deficiency upon clinical presentation in nasal polyposis"],"prefix":"10.1002","volume":"4","author":[{"given":"Rodney J.","family":"Schlosser","sequence":"first","affiliation":[{"name":"Department of Surgery Ralph H. Johnson VA Medical Center  Charleston SC"},{"name":"Division of Rhinology &amp; Sinus Surgery Department of Otolaryngology Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary M.","family":"Soler","sequence":"additional","affiliation":[{"name":"Division of Rhinology &amp; Sinus Surgery Department of Otolaryngology Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Schmedes","sequence":"additional","affiliation":[{"name":"Division of Rhinology &amp; Sinus Surgery Department of Otolaryngology Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Storck","sequence":"additional","affiliation":[{"name":"Division of Rhinology &amp; Sinus Surgery Department of Otolaryngology Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Mulligan","sequence":"additional","affiliation":[{"name":"Department of Surgery Ralph H. Johnson VA Medical Center  Charleston SC"},{"name":"Division of Rhinology &amp; Sinus Surgery Department of Otolaryngology Medical University of South Carolina  Charleston SC"},{"name":"Department of Pediatrics Division of Neonatology Medical University of South Carolina  Charleston SC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3228"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200808-1361OC"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.6.3792"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.038"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04325.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812448852"},{"issue":"23","key":"e_1_2_6_8_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","volume":"3","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989411100508"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0435"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.017"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21274","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:00:27Z","timestamp":1696618827000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,10]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1002\/alr.21274"],"URL":"https:\/\/doi.org\/10.1002\/alr.21274","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718237297.793492224","asserted-by":"object"}]},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,10]]}}}