{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:07:01Z","timestamp":1791227221195,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T00:00:00Z","timestamp":1389312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recent evidence implicates polymorphisms of the bitter taste receptor <jats:italic>TAS2R38<\/jats:italic> as defining characteristics in respiratory innate defense that may contribute to the complex genetic and environmental interactions predisposing to chronic rhinosinusitis (CRS). The purpose of this study was to (1) verify whether identified polymorphisms associated with respiratory infection in taste receptors replicate within our existing population of patients with CRS and (2) identify other taste receptors potentially associated with CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pooling\u2010based genomewide association studies (pGWAS) were previously performed on 2 populations of Canadian CRS patients (genetics of chronic rhinosinusitis 1, refractory CRS [GCRS1]; and genetics of chronic rhinosinusitis 2, CRS with nasal polyposis [GCRS2]) using the Illumina HumanHap 1\u2010M chip. The pGWAS data were screened for polymorphisms in taste receptor genes. Single\u2010nucleotide polymorphisms (SNPs) were considered replicated when the allele frequency differences were \u226510% in cases compared to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The previously identified <jats:italic>TAS2R38<\/jats:italic> coding SNP rs10246939 (I296V) was associated with CRS in both populations. The difference in allele frequency in cases compared to control subjects was 11% in GCRS1 and 15% in GCRS2. In addition, 3 previously undescribed missense variants were associated with CRS in our populations: 1 in the <jats:italic>TAS2R13<\/jats:italic> gene (rs1015443), and the others in the <jats:italic>TAS2R49<\/jats:italic> gene (rs12226920, rs12226919).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study replicates previous work which showed that the coding SNP rs10246939 in the <jats:italic>TAS2R38<\/jats:italic> gene is associated with CRS. Moreover, the results suggest that other taste receptors may be implicated in CRS. Further studies using individual genotyping and sequencing, and functional studies will provide more information about the implication of these genetic variants in CRS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21275","type":"journal-article","created":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T18:38:46Z","timestamp":1389379126000},"page":"200-206","source":"Crossref","is-referenced-by-count":99,"title":["Genetic variations in taste receptors are associated with chronic rhinosinusitis: a replication study"],"prefix":"10.1002","volume":"4","author":[{"given":"Leandra","family":"Mfuna Endam","sequence":"first","affiliation":[{"name":"Department of Otolaryngology H\u00f4tel\u2010Dieu Hospital, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM)  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelali","family":"Filali\u2010Mouhim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology H\u00f4tel\u2010Dieu Hospital, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM)  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Boisvert","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Saint\u2010Fran\u00e7ois d'Assise Hospital  Qu\u00e9bec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis\u2010Philippe","family":"Boulet","sequence":"additional","affiliation":[{"name":"Centre de Recherche Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec  Qu\u00e9bec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohan","family":"Boss\u00e9","sequence":"additional","affiliation":[{"name":"Centre de Recherche Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec  Qu\u00e9bec QC Canada"},{"name":"Department of Molecular Medicine Laval University  Qu\u00e9bec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Desrosiers","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology H\u00f4tel\u2010Dieu Hospital, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM)  Montreal QC Canada"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Montreal General Hospital McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80705-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M513637200"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.072090199"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/35007072"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjq027"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05453.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0091-10.2010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80706-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05401"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2012.08.006"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature726"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1531172100"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2237"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64240"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.042617699"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.02.016"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2011.02308.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00077712"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.01.047"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20203"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2004.00361.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21140"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-009-0626-9"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.09.067"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1086\/510686"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg930"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm1060"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20517"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-4-81"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm435"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn324"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00066.2008"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01195.2007"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911934107"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21275","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T23:00:28Z","timestamp":1696633228000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,10]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1002\/alr.21275"],"URL":"https:\/\/doi.org\/10.1002\/alr.21275","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,10]]}}}