{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:25:45Z","timestamp":1786976745223,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T00:00:00Z","timestamp":1393977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"\n Background<\/jats:title>\n Treatment options for chronic rhinosinusitis with recurrent polyposis (CRSwNP) after endoscopic sinus surgery (ESS) are limited, and include frequent use of systemic steroids and revision surgery. A bioabsorbable, steroid\u2010eluting implant was studied for its ability to dilate sinuses obstructed by polyps and provide localized, controlled steroid delivery to reestablish sinus patency. This study assessed the initial feasibility, safety, and efficacy of steroid\u2010eluting implants placed in the office setting in patients who were candidates for revision ESS.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Prospective, multicenter study enrolling 12 patients who had prior ESS but experienced recurrent polyposis refractory to medical therapy. Implants were placed bilaterally under topical anesthesia in\u2010office. Follow\u2010up through 6\u00a0months included endoscopic grading, patient\u2010reported outcomes (22\u2010item Sino\u2010Nasal Outcomes Test [SNOT\u201022]) and need for revision ESS.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Implants were successfully inserted in 21 of 24 (88%) ethmoid sinuses, resulting in 11 evaluable patients. No serious adverse events occurred. Within 1\u00a0month, mean bilateral polyp grade was reduced from 4.5 at baseline to 2.3 (\n p<\/jats:italic>\n = 0.008) and sustained through 6\u00a0months (2.33;\n p<\/jats:italic>\n = 0.008). Mean SNOT\u201022 score was significantly improved from 2.19 at baseline to 0.90 within 1\u00a0month (\n p<\/jats:italic>\n = 0.001) and sustained to 6\u00a0months (1.03;\n p<\/jats:italic>\n = 0.012). Sixty\u2010four percent of patients were no longer revision ESS candidates at 6\u00a0months.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The study provided initial clinical evidence of the feasibility, safety, and efficacy of in\u2010office steroid\u2010eluting implant placement in CRS patients with recurrent polyposis after ESS. Although further studies are needed, the results suggest this therapy may provide a safe and effective, office\u2010based option for the treatment of obstructive polyposis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/alr.21309","type":"journal-article","created":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T10:06:17Z","timestamp":1394013977000},"page":"381-389","source":"Crossref","is-referenced-by-count":46,"title":["Steroid\u2010eluting sinus implant for in\u2010office treatment of recurrent nasal polyposis: a prospective, multicenter study"],"prefix":"10.1002","volume":"4","author":[{"given":"Fran\u00e7ois","family":"Lavigne","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM) H\u00f4pital Notre\u2010Dame Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K.","family":"Miller","sequence":"additional","affiliation":[{"name":"Intermountain ENT Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Gould","sequence":"additional","affiliation":[{"name":"Advanced ENT & Allergy Louisville KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent J.","family":"Lanier","sequence":"additional","affiliation":[{"name":"Central California ENT Fresno CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Lewis","family":"Romett","sequence":"additional","affiliation":[{"name":"Colorado ENT & Allergy Colorado Springs CO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.2979"},{"issue":"20","key":"e_1_2_7_3_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2007","author":"Fokkens W","year":"2007","journal-title":"Rhinol Suppl"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200405000-00004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20020"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22228"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811435968"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21044"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199304050-00006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.121022"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1985.tb05069.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.12.1144"},{"key":"e_1_2_7_14_1","first-page":"513","article-title":"Results of oral steroid treatment in nasal polyposis","volume":"124","author":"Camp C","year":"1998","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.03.012"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000225896.91392.6a"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2009.07.009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-154-5-201103010-00003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065890782018118"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164800454279"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31806865be"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.07.014"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.2.179"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.07.027"},{"key":"e_1_2_7_25_1","volume-title":"The National Comparative Audit of Surgery for Nasal Polyposis and Chronic Rhinosinusitis","author":"Browne J"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.05.010"}],"container-title":["International Forum of Allergy & Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:22:32Z","timestamp":1696620152000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,5]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1002\/alr.21309"],"URL":"https:\/\/doi.org\/10.1002\/alr.21309","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718300774.793492523","asserted-by":"object"}]},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,5]]}}}