{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T06:26:17Z","timestamp":1775543177384,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T00:00:00Z","timestamp":1393804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Functional endoscopic sinus surgery (FESS) has become the treatment of choice for patients with medically resistant chronic rhinosinusitis (CRS) and nasal polyps. Despite the consolidated use of different treatments, the postoperative period is often very painful and uncomfortable, especially during the first month. Although evidence on the effectiveness of sodium hyaluronate (SH) on postoperative care following FESS is available, data on the quality of life (QoL) from the patients\u2019 perspective are still lacking. This study aimed to evaluate for the first time the effectiveness of nasal douche with SH in reducing patients\u2019 discomfort during the first month following FESS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A double\u2010blind randomized controlled study was carried out on 124 subjects undergoing FESS for CRS with nasal polyposis. They were divided into 2 groups: group I was treated with nasal douche containing 9 mg of high molecular weight SH plus saline solution and group II was treated with saline solution alone. To assess QoL in CRS patients, the Short Form\u201036 (SF\u201036) test, the Sino\u2010Nasal Outcome Test\u201022 (SNOT\u201022), and the visual analogue scale (VAS) questionnaires were administered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, there were no statistically significant differences between the 2 groups. However, after 30 days of long postoperative treatments, we found clinically significant improvements in QoL of subjects treated with SH, as evidenced by all QoL scales.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data indicate that SH significantly improves patients\u2019 short\u2010term QoL following FESS in terms of both general health and specific sinonasal status.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21310","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T15:39:06Z","timestamp":1393861146000},"page":"484-487","source":"Crossref","is-referenced-by-count":39,"title":["Impact of intranasal sodium hyaluronate on the short\u2010term quality of life of patients undergoing functional endoscopic sinus surgery for chronic rhinosinusitis"],"prefix":"10.1002","volume":"4","author":[{"given":"Elena","family":"Cantone","sequence":"first","affiliation":[{"name":"Department of Neuroscience Reproductive and Odontostomatologic Science ENT Unit \u201cFederico II\u201d University  Naples Italy"},{"name":"Department of Molecular Medicine and Medical Biotechnology \u201cFederico II\u201d University  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Castagna","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Reproductive and Odontostomatologic Science ENT Unit \u201cFederico II\u201d University  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Sicignano","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Reproductive and Odontostomatologic Science ENT Unit \u201cFederico II\u201d University  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Immacolata","family":"Ferranti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Reproductive and Odontostomatologic Science ENT Unit \u201cFederico II\u201d University  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felice","family":"Rega","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Reproductive and Odontostomatologic Science ENT Unit \u201cFederico II\u201d University  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittoria","family":"Di Rubbo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Reproductive and Odontostomatologic Science ENT Unit \u201cFederico II\u201d University  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Iengo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Reproductive and Odontostomatologic Science ENT Unit \u201cFederico II\u201d University  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02646.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2012.01322.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21072"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21064"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21096"},{"issue":"3","key":"e_1_2_6_7_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","volume":"23","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0036com"},{"key":"e_1_2_6_9_1","first-page":"103","article-title":"Effect of sodium hyaluronate on mucociliary clearance after functional endoscopic sinus surgery","volume":"45","author":"Gelardi M","year":"2013","journal-title":"Eur Ann Allergy Clin Immunol."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201302600113"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3833"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21193"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_6_14_1","first-page":"22","article-title":"Medical management of sinusitis: educational goals and management guidelines. 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