{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:35:51Z","timestamp":1761708951637},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T00:00:00Z","timestamp":1395014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Identification of <jats:italic>Staphylococcus aureus<\/jats:italic> intracellularly in chronic rhinosinusitis (CRS) suggests an underlying cellular immunodeficiency. Supporting this, we have previously reported low CD8+ (cytotoxic) T\u2010lymphocyte levels in a subpopulation of CRS patients and identified polymorphisms in the CD8A gene associated with CRS. In order to better understand the role of low CD8+ in CRS, we wished to determine the phenotype for CRS\/Low CD8+ in comparison to that of conventional CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010seven low CD8+ CRS patients identified during investigation of CRS were compared for demographics, disease evolution, and bacteriology on endoscopic culture were compared with an existing population of 480 patients with CRS with nasal polyposis previously recruited for genetic association studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean level of CD8+ in the CRS\/Low CD8+ population was 0.15 \u00d7 10<jats:sup>9<\/jats:sup>\/L (range, 0.20\u20131.5 \u00d7 10<jats:sup>9<\/jats:sup>\/L). There was no difference between both groups in terms of history of allergy, asthma, eczema, acetylsalicylic acid (ASA) intolerance or smoking. The bacteriology was similar between both groups (<jats:italic>S. aureus<\/jats:italic>: CRS\/Low CD8+: 35%; CRS 32%, <jats:italic>p<\/jats:italic> = 0.643). Evolution of disease was somewhat milder in CRS\/Low CD8+, with fewer patients requiring surgery, and first surgery performed at a more advanced age. However, antibiotic use was higher in CRS\/Low CD8+. Subgroup analysis restricted to CRS with nasal polyposis (CRSwNP)\/Low CD8 or CRS without nasal polyposis (CRSsNP)\/Low CD8 phenotypes did not substantially alter these results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low CD8+ levels are often identified in CRS patients; however, these patients have disease remarkably similar to those with conventional CRS. This suggests that immune deficiency, whether systemic or locally mediated, is well tolerated and may be present in other forms in CRS. CRS patients with low CD8+ levels may possibly require antibacterial therapies as part of ongoing management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21313","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T15:32:55Z","timestamp":1395070375000},"page":"495-501","source":"Crossref","is-referenced-by-count":12,"title":["Clinical features of cytotoxic CD8+ T\u2010lymphocyte deficiency in chronic rhinosinusitis patients: a demographic and functional study"],"prefix":"10.1002","volume":"4","author":[{"given":"Nathalie","family":"Gabra","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Montreal  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saud","family":"Alromaih","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandra Mfuna","family":"Endam","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM)  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose Marie","family":"Brito","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire (CHU) Sainte\u2010Justine Research Center  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Larivi\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawsan","family":"Al\u2010Mot","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM)  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"LeDeist","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire (CHU) Sainte\u2010Justine Research Center  Montreal Quebec Canada"},{"name":"Department of Microbiology Infectiology, and Immunology University of Montreal  Montreal Quebec Canada"},{"name":"Department of Pediatrics University of Montreal  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Desrosiers","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM)  Montreal Quebec Canada"},{"name":"Centre Hospitalier Universitaire (CHU) Sainte\u2010Justine Research Center  Montreal Quebec Canada"},{"name":"Department of Microbiology Infectiology, and Immunology University of Montreal  Montreal Quebec Canada"},{"name":"Department of Pediatrics University of Montreal  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