{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:55:49Z","timestamp":1788623749189,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T00:00:00Z","timestamp":1395360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study assessed efficacy of clarithromycin \u201clong\u2010term\u201d macrolide therapy as an adjunct to maintenance therapy with nasal corticosteroids to prevent recurrence of nasal polyps (NP) after functional endoscopic sinus surgery (FESS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 66 patients with chronic rhinosinusitis and bilateral NP were randomized into 3 study arms, 22 patients in each arm. After FESS, patients in the first and second groups were treated with clarithromycin 250\u00a0mg\/day for 12 and 24\u00a0weeks, respectively, whereas patients in the third group did not receive any clarithromycin. Patients in all 3 groups received maintenance therapy with mometasone furoate 400 \u03bcg\/day. Patient assessment was conducted before the surgery and 6, 12, and 24\u00a0weeks after surgery, using a visual analogue scale (VAS), 20\u2010item SinoNasal Outcome Test (SNOT\u201020), acoustic rhinometry, rhinomanometry, saccharin transit time, nasal endoscopy, computed tomography (CT) of paranasal sinuses, and measurement of the level of eosinophil cationic protein (ECP) in their nasal secretions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study confirmed efficacy of \u201clong\u2010term\u201d macrolide therapy, resulting in significant improvement of all parameters except acoustic rhinometry and VAS in both clarithromycin groups as compared to the control. Concentration of ECP in the nasal secretions increased dramatically after surgery, then returned to baseline levels after 12 and 24\u00a0weeks of treatment with clarithromycin. In the control group, ECP level continued to increase and was significantly higher at the endpoint. Both groups with clarithromycin showed significantly better endoscopic and CT scores than the control group at the end point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>\u201cLong\u2010term\u201d low\u2010dose clarithromycin 250\u00a0mg\/day is able to control eosinophilic inflammation and prevent early relapse of NP after FESS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21318","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T14:47:28Z","timestamp":1395413248000},"page":"533-541","source":"Crossref","is-referenced-by-count":53,"title":["Efficacy of long\u2010term low\u2010dose macrolide therapy in preventing early recurrence of nasal polyps after endoscopic sinus surgery"],"prefix":"10.1002","volume":"4","author":[{"given":"Anastasia","family":"Varvyanskaya","sequence":"first","affiliation":[{"name":"Ear, Nose, and Throat (ENT) Clinic Sechenov First Moscow State Medical University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Lopatin","sequence":"additional","affiliation":[{"name":"Ear, Nose, and Throat (ENT) Clinic Sechenov First Moscow State Medical University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.4.717"},{"key":"e_1_2_7_3_1","first-page":"17","volume-title":"Nasal Polyps: Epidemiology, Pathogenesis and Treatment","author":"Settipane G","year":"1997"},{"key":"e_1_2_7_4_1","first-page":"21","article-title":"Aspirin\u2010induced asthma and nasal polyps","volume":"430","author":"Ogino S","year":"1986","journal-title":"Acta Otolaryngol Suppl"},{"issue":"20","key":"e_1_2_7_5_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps group. 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