{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:27:52Z","timestamp":1786976872378,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T00:00:00Z","timestamp":1397001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Potassium\u2010titanyl\u2010phosphate (KTP) laser photocoagulation is commonly used for treatment of hereditary hemorrhagic telangiectasia\u2010related epistaxis (HHT\u2010RE). Electrosurgical plasma coagulation (EPC), also known as coblation, has not been rigorously evaluated for HHT\u2010RE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients seeking treatment for HHT\u2010RE between September 2010 and September 2012 were prospectively randomized (1:1) to KTP or EPC in a single blind prospective cohort study. Length of surgery and estimated blood loss (EBL) were recorded. Epistaxis severity scores (ESSs) and 10\u2010cm visual analogue scale (VAS) scores for HHT\u2010RE\u2013related symptoms were administered at enrollment and at 3, 6, 12 months following surgery. Statistical analysis used Friedman's and Pearson's chi\u2010square tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eleven HHT patients were prospectively enrolled and followed. Six patients underwent EPC treatment while 5 underwent KTP. Three patients in the KTP subgroup and 2 patients in the EPC subgroup requested additional surgical treatment within 12 months (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.999). There were no significant differences in terms of EBL (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.126) and length of surgery (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.429) between treatment groups. Mean ESSs were not significantly different between groups at any follow\u2010up point (KTP,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.896; EPC,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.159). Compared to KTP, mean ESSs were higher in the EPC subgroup at baseline and lower at all other time points. Mean nasal obstruction VAS scores were significantly lower in the EPC subgroup at all follow\u2010up points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EPC is a viable alternative to KTP laser photocoagulation for epistaxis control in patients with HHT. Subjectively, patients experience less nasal obstruction following EPC as compared to KTP treatment. A multicentered, well\u2010powered study is warranted to better determine treatment outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alr.21328","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T11:15:15Z","timestamp":1397042115000},"page":"640-645","source":"Crossref","is-referenced-by-count":29,"title":["Comparison of electrosurgical plasma coagulation and potassium\u2010titanyl\u2010phosphate laser photocoagulation for treatment of hereditary hemorrhagic telangiectasia\u2010related epistaxis"],"prefix":"10.1002","volume":"4","author":[{"given":"Lauren","family":"Luk","sequence":"first","affiliation":[{"name":"Oregon Sinus Center Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University  Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess C.","family":"Mace","sequence":"additional","affiliation":[{"name":"Oregon Sinus Center Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University  Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen D.","family":"Bhandarkar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California Irvine  Irvine CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan B.","family":"Sautter","sequence":"additional","affiliation":[{"name":"Oregon Sinus Center Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health and Science University  Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.069013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320320302"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000154749.09303.e0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989110500507"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3145"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1088\/0022-3727\/38\/11\/014"},{"key":"e_1_2_6_8_1","first-page":"1","author":"ArthroCare Corporation","year":"2008","journal-title":"Coblation Technology"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(03)00361-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199901000-00004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900113"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900515"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200205000-00001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100136370"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198712000-00004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-991183"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000306)91:1<66::AID-AJMG12>3.0.CO;2-P"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20818"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2231"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240602000116"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.05.013"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21328","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T11:57:40Z","timestamp":1696593460000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,9]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1002\/alr.21328"],"URL":"https:\/\/doi.org\/10.1002\/alr.21328","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,9]]}}}