{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:54:01Z","timestamp":1769111641744,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T00:00:00Z","timestamp":1397433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Nasopharyngeal squamous cell carcinoma (NPSCC) is uncommon in non\u2010endemic regions. Two major histologic subtypes are recognized: keratinizing (K\u2010NPSCC) and nonkeratinizing (NK\u2010NPSCC). We hypothesize that significant differences exist between the 2 in terms of demographic, clinicopathologic, survival, and prognostic features. We aim to show that differentiating between the 2 subtypes is perhaps the most important first step at the time of diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a retrospective cohort design, the U.S. National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry was used to extract data on the 2 major subtypes of NPSCC. Frequency, incidence, and relative survival (RS) were analyzed comparatively. Regression analysis was conducted and hazard ratios (HRs) calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1624 cases were identified: 1234 (76.0%) cases of NK\u2010NPSCC and 390 (24.0%) cases of K\u2010NPSCC. Five\u2010year RS was 60.6% for NK\u2010NPSCC and 40.5% for K\u2010NPSCC. Regression analysis revealed K\u2010NPSCC to be a poor prognostic factor (HR 2.1; 95% confidence interval, 1.8\u20132.6; <jats:italic>p<\/jats:italic> &lt; 0.0001). Other factors associated with a poor prognosis included female gender in K\u2010NPSCC, age greater than 44\u00a0years in both groups, and advanced\u2010stage disease at diagnosis. Favorable prognostic factors included Asian\/Pacific Islander race, and treatment with radiation therapy. Higher histologic grade did not portend a worse prognosis for either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NPSCC remains an uncommon malignancy in the United States. K\u2010NPSCC and NK\u2010NPSCC represent 2 different histologic entities with important clinical differences. K\u2010NPSCC carries a worse overall prognosis when compared to NK\u2010NPSCC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21332","type":"journal-article","created":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T18:54:42Z","timestamp":1397501682000},"page":"675-683","source":"Crossref","is-referenced-by-count":45,"title":["Nasopharyngeal squamous cell carcinoma: a comparative analysis of keratinizing and nonkeratinizing subtypes"],"prefix":"10.1002","volume":"4","author":[{"given":"Alejandro","family":"Vazquez","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohemmed N.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Rutgers New Jersey Medical School  Newark NJ"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mount Sinai School of 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