{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:45:23Z","timestamp":1792568723102,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T00:00:00Z","timestamp":1398211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sinonasal lymphoma is a rare rhinologic entity. We present a case series and review the literature surrounding the diagnosis and management of this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A pathology database spanning 22 years at a tertiary care center was searched for a diagnosis of lymphoma in the paranasal sinuses or the nasal cavity. Seventeen cases were identified, and retrospective chart review was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maxillary and ethmoid sinuses were affected more frequently (n = 8 patients each) than sphenoid and frontal sinuses (n = 5 patients each). Histologically, the most common type was diffuse large B\u2010cell lymphoma (53%, 9 patients), followed by extranodal natural killer\/T\u2010cell lymphoma (ENKL, 21%, 3 patients). Presenting symptoms included nasal obstruction and rhinorrhea (53%, 9 patients) and diplopia (18%, 3 patients); and radiographic imaging demonstrated a discrete mass (59%, 10 patients), sinus opacification (53%, 9 patients), and\/or bony erosion (35%, 6 patients). Treatment included chemotherapy alone (71%, 12 patients), chemotherapy and radiation (6%, 1 patient), and radiation alone (6%, 1 patient). The 2\u2010year and 5\u2010year overall survival rates were 75% and 53%, respectively, whereas disease\u2010free 2\u2010year and 5\u2010year survival rates were 70% and 49%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lymphoma of the nasal cavity and paranasal sinuses is extremely rare, may mimic benign processes, and may manifest either in an isolated fashion or in conjunction with systemic disease. B\u2010cell lymphomas, a more favorable diagnosis, account for a majority of cases, whereas ENKL is associated with rapid disease progression and death. Chemotherapy and radiation are the main therapies. Histologic diagnosis is of paramount importance, and clinicians must remain cognizant of this entity to differentiate it from other sinonasal malignancies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21337","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T14:29:00Z","timestamp":1398263340000},"page":"670-674","source":"Crossref","is-referenced-by-count":52,"title":["Sinonasal lymphoma: case series and review of the literature"],"prefix":"10.1002","volume":"4","author":[{"given":"Kevin A.","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at the University of California  Los Angeles Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley E.","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at the University of California  Los Angeles Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at the University of California  Los Angeles Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita M.","family":"Bhuta","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine David Geffen School of Medicine at the University of California  Los Angeles Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilene B.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at the University of California  Los Angeles Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60605-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01490-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410301116"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11908"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1986.tb02540.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2825"},{"key":"e_1_2_6_8_1","first-page":"331","article-title":"Midline destructive lesions of the sinonasal tract: simplified terminology based on histopathologic criteria","volume":"21","author":"Borges A","year":"2000","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199911000-00006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2003.10.011"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1983.93.10.1276"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70192-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1839-9"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20015"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970801)80:3<477::AID-CNCR16>3.0.CO;2-U"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190903186502"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950315)75:6<1281::AID-CNCR2820750610>3.0.CO;2-I"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(00)00094-8"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(00)00069-9"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2395"}],"container-title":["International Forum of Allergy &amp; 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