{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:17:02Z","timestamp":1774340222533,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T00:00:00Z","timestamp":1404259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the present study was to measure eotaxin\u20103 (CCL26) and eotaxin\u20102 (CCL24) in nasal lavage fluid of patients with different forms of chronic sinonasal eosinophilic inflammation to evaluate their role in the pathophysiology of nasal hypereosinophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was an analytic cross\u2010section study, level of evidence 3b. Patients (n = 80) with nasal hypereosinophilia were randomly recruited and grouped in the following categories: persistent allergic rhinitis (AR) (n = 25), nonallergic rhinitis with eosinophilia syndrome (NARES) (n = 30), and chronic rhinosinusitis with polyps (CRSwNP) (n = 25). Non\u2010rhinitic volunteers (n = 20) were recruited as controls. CCL24 and CCL26 concentrations were measured by enzyme\u2010linked immunosorbent assay (ELISA) Quantikine Human Immunoassays (R&amp;D Systems, Minneapolis, MN) in nasal lavage fluids. Differential cell counts were performed by microscopic cytological examination of nasal tissue scraped from the inferior turbinate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean CCL26 levels were significantly higher (<jats:italic>p<\/jats:italic> &lt; 0.05) in AR and in NARES (132.0\u00a0pg\/mL and 187.63\u00a0pg\/mL, respectively) than in the control group (13.5\u00a0pg\/mL); in patients with CRSwNP, CCL26 values were increased compared to controls even though the difference was not statistically significant (58.9\u00a0pg\/mL vs 16.5\u00a0pg\/mL). Mean CCL24 levels measured in AR, NARES, and CRSwNP were significantly increased (<jats:italic>p<\/jats:italic> &lt; 0.05) compared to controls (96.7\u00a0pg\/mL, 135.4\u00a0pg\/mL, and 107.0\u00a0pg\/mL, respectively, vs 32.2\u00a0pg\/mL). Moreover, we observed a significant correlation between CCL24 and CCL26 levels, evaluating them intraindividually by Spearman's rank correlation test. Finally, a significant correlation was found between CCL24 and CCL26 levels and the percentage of eosinophilic infiltration of nasal mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data suggest that CCL26 and CCL24 are likely involved in the pathogenesis of chronic nasal hypereosinophilia, with a complex cooperation and different involvement of the various members of eotaxin family. Further studies are necessary to better understand the actual physiopathologic mechanism, possible clinical relevance, and therapeutic implications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21348","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T15:52:03Z","timestamp":1404316323000},"page":"617-624","source":"Crossref","is-referenced-by-count":33,"title":["Nasal fluid release of eotaxin\u20103 and eotaxin\u20102 in persistent sinonasal eosinophilic inflammation"],"prefix":"10.1002","volume":"4","author":[{"given":"Eugenio","family":"De Corso","sequence":"first","affiliation":[{"name":"Department Head and Neck Surgery\u2013Institute of Otorhinolaryngology Catholic University School of Medicine and Surgery  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Baroni","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Laboratory Medicine\u2013Institute of Biochemistry and Clinical 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