{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:43:36Z","timestamp":1783464216409,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T00:00:00Z","timestamp":1410739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The prognostic value of the tumor burden characterized by the metabolic tumor volume (MTV) remains under investigation in nasopharyngeal carcinoma (NPC). The purpose of this study was to evaluate the prognostic value of the maximum standardized uptake value (SUV<jats:sub>max<\/jats:sub>) and MTV according to metabolic volume threshold as measured by positron emission tomography (PET)\/computed tomography (CT), and other clinical factors, in patients with NPC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a retrospective chart review. We evaluated the association of SUV<jats:sub>max<\/jats:sub>, MTV<jats:sub>2.5<\/jats:sub>, MTV<jats:sub>3.0<\/jats:sub>, and other clinical factors with overall survival (OS) using Kaplan\u2010Meier and Cox regression models. (MTV<jats:sub>2.5<\/jats:sub> and MTV<jats:sub>3.0<\/jats:sub> are the volume of hypermetabolic tissue within the regions of gross tumor volumes with a SUV value greater than the threshold values of 2.5 and 3.0, respectively.)<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher MTV<jats:sub>2.5<\/jats:sub> of 31.45 cm<jats:sup>3<\/jats:sup> and MTV<jats:sub>3.0<\/jats:sub> of 23.01\u00a0cm<jats:sup>3<\/jats:sup> were associated with an increased risk of death (hazard ratio [HR] = 5.028; <jats:italic>p<\/jats:italic> = 0.029), although no significant relationship was found between SUV<jats:sub>max<\/jats:sub> and OS. Interestingly, MTV<jats:sub>3.0<\/jats:sub> was associated with OS in both the differentiated and undifferentiated groups, although MTV<jats:sub>2.5<\/jats:sub> was only associated with OS in the undifferentiated group. Among the clinical parameters, only radiotherapy was associated with longer OS (HR = 12.124; <jats:italic>p<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The MTV and radiotherapy could be prognostic values associated with OS. Particularly, MTV<jats:sub>2.5<\/jats:sub> and MTV<jats:sub>3.0<\/jats:sub> might be valuable metabolic parameters for predicting long\u2010term survival in patients with NPC. Furthermore, MTV<jats:sub>3.0<\/jats:sub> may be more useful because it can be applied irrespective of pathologic subtype.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21363","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T15:19:45Z","timestamp":1410794385000},"page":"845-850","source":"Crossref","is-referenced-by-count":19,"title":["Prognostic value of metabolic tumor volume as measured by fluorine\u201018\u2010fluorodeoxyglucose positron emission tomography\/computed tomography in nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"4","author":[{"given":"Young\u2010Ho","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Biomedical Research Institute Pusan National University School of Medicine Pusan National University Hospital  Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok\u2010Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Biomedical Research Institute Pusan National University School of Medicine Pusan National University Hospital  Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Lyong","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Biomedical Research Institute Pusan National University School of Medicine Pusan National University Hospital  Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Jang","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Pusan National University School of Medicine Pusan National University Hospital  Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan\u2010Jung","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital  Yangsan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu\u2010Sup","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Biomedical Research Institute Pusan National University School of Medicine Pusan National University Hospital  Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-009-0729-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2008.10.006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2013.14.1.1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-002-0341-6"},{"key":"e_1_2_6_6_1","first-page":"252","article-title":"In vitro comparison of cell proliferation kinetics and uptake of tritiated fluorodeoxyglucose and L\u2010methionine in squamous\u2010cell carcinoma of the head and neck","volume":"36","author":"Minn H","year":"1995","journal-title":"J Nucl Med"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880501)61:9<1776::AID-CNCR2820610909>3.0.CO;2-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841860903440270"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0719-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.12.039"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.01.009"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600114"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.02.590"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.03.026"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.04.036"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.10.044"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.111.101402"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.10.060"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.082404"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.179.5.1791337"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.11.002"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyg092"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.011"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360178"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27853"}],"container-title":["International Forum of Allergy &amp; 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