{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T03:06:54Z","timestamp":1777000014809,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T00:00:00Z","timestamp":1415750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Respiratory epithelial adenomatoid hamartomas (REAHs) are rare benign tumors and may manifest as either isolated lesions or in association with sinonasal polyposis. The aim of this study is to report our experience in the management of patients with REAH and to analyze the long\u2010term results of the endoscopic endonasal approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of a database dedicated to patients with REAH treated between May 2003 and December 2012 was performed. Clinical presentation, demographic, histologic and radiographic features, operative findings, and follow\u2010up data were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven patients with REAH, 14 males and 13 females, with a mean age of 51 years, underwent endoscopic sinus surgery (ESS). The most frequent reported symptoms were nasal obstruction (80%), headache (12%), mucous rhinorrhea (20%), and hyposmia (40%). Seventeen cases (first group) were present as isolated masses, 10 cases (second group) were associated with nasal polyposis. The first group with a preoperative diagnosis of REAH was submitted to a more aggressive resection with subperiosteal dissection and drilling of the underlying bone. The patients in the second group, because of the unrevealed diagnosis of REAH and due to the presence of nasal polyposis, underwent standard ESS. No evidence of recurrence in either of the subgroups after a mean follow\u2010up of 61.2 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>REAH is a benign well\u2010defined pathological entity but is still unfamiliar. REAH should be kept in mind as a differential diagnosis from more aggressive lesions to avoid unnecessary surgical procedure. A complete but conservative endoscopic resection appears to be curative.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21372","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T17:13:28Z","timestamp":1415812408000},"page":"961-965","source":"Crossref","is-referenced-by-count":20,"title":["Endoscopic endonasal resection of respiratory epithelial adenomatoid hamartomas of the sinonasal tract"],"prefix":"10.1002","volume":"4","author":[{"given":"Maurizio","family":"Bignami","sequence":"first","affiliation":[{"name":"Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences University of Insubria  Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Volpi","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology Department of Surgical, Microsurgical and Medical Sciences, University of Sassari  Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apostolos","family":"Karligkiotis","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology Department of Surgical, Microsurgical and Medical Sciences, University of Sassari  Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"De Bernardi","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences University of Insubria  Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Pistochini","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences University of Insubria  Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AbdulAziz","family":"AlQahtani","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences University of Insubria  Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Meloni","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology Department of Surgical, Microsurgical and Medical Sciences, University of Sassari  Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Verillaud","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Lariboisi\u00e8re H\u00f4pital, Assistance Publique\u2013H\u00f4pitaux de Paris Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, EA Recherche Clinique Cordonn\u00e9e Ville\u2010H\u00f4pital, M\u00e9thodologies et Soci\u00e9t\u00e9 (REMES)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Herman","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Lariboisi\u00e8re H\u00f4pital, Assistance 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