{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:38:13Z","timestamp":1790649493106,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T00:00:00Z","timestamp":1411603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>It is unclear whether chronic rhinosinusitis (CRS) patients with both nasal polyps and asthma have different quality of life (QOL) improvement after functional endoscopic sinus surgery (FESS). We aimed to determine whether CRS patients with asthma and nasal polyps had a greater QOL improvement after FESS compared to patients without asthma or polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective analysis included adult CRS patients who underwent FESS between 2007 and 2011. QOL was measured using the 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022). Variables collected included baseline demographics, clinical factors, SNOT\u201022 scores before FESS, and 1 month, 3 months, and 6 months post\u2010FESS. Groups tested were asthma alone, polyps alone, asthma and polyps, and no asthma or polyps. Linear mixed\u2010effects regression model was performed to calculate \u03b2\u2010coefficients, which represent the adjusted mean QOL differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 376 patients included, 40.16% had both asthma and polyps (n = 151), 14.36% had asthma alone (n = 54), 19.45% had polyps alone (n = 75), and 25.53% had no asthma or polyps (n = 96). After adjusting for all factors, there were significantly more QOL improvements in patients with both asthma and nasal polyps from baseline to 1\u2010month (\u03b2\u2010coefficient = \u221210.05; 95% CI, \u221215.86 to \u22124.23; <jats:italic>p<\/jats:italic> = 0.001) and 3\u2010month follow\u2010up (\u03b2\u2010coefficient = \u22128.27; 95% CI, \u221214.98 to \u22121.56; <jats:italic>p<\/jats:italic> = 0.016), and patients with asthma alone from baseline to 6\u2010month follow\u2010up (\u03b2\u2010coefficient = \u22128.78; 95% CI, \u221217.45 to \u22120.11; <jats:italic>p<\/jats:italic> = 0.047), when compared to patients without asthma or nasal polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CRS patients with both asthma and nasal polyps or asthma alone experience a larger QOL benefit from FESS immediately after FESS compared to CRS patients without asthma or polyps.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21406","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T14:31:58Z","timestamp":1411655518000},"page":"885-892","source":"Crossref","is-referenced-by-count":44,"title":["Quality of life improvement from sinus surgery in chronic rhinosinusitis patients with asthma and nasal polyps"],"prefix":"10.1002","volume":"4","author":[{"given":"Zi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Epidemiology Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Perelman School of Medicine  Philadelphia PA U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithin D.","family":"Adappa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania Perelman School of Medicine  Philadelphia PA U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel J.","family":"Doghramji","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania Perelman School of Medicine  Philadelphia PA U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Arizona  Tucson AZ U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebbing","family":"Lautenbach","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Perelman School of Medicine  Philadelphia PA U.S.A"},{"name":"Division of Infectious Diseases Department of Medicine University of Pennsylvania Perelman School of Medicine  Philadelphia PA U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania Perelman School of Medicine  Philadelphia PA U.S.A"},{"name":"Philadelphia Veterans Affairs Medical Center  Philadelphia PA U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Pennsylvania Perelman School of Medicine  Philadelphia PA 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