{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:00:15Z","timestamp":1785297615014,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T00:00:00Z","timestamp":1410739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with cystic fibrosis (CF) exhibit a wide range of disease severity, and can be broadly stratified into high\u2010risk and low\u2010risk groups based on cystic fibrosis transmembrane conductance regulator (CFTR) mutation class. Patients with a low\u2010risk genotype are often diagnosed as adults, with milder disease and lower sweat chloride values. The aim of the current study was to better understand radiographic and clinical characteristics of sinus disease in adult CF patients within this risk category.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult CF patients were retrospectively compared to a control group of patients with chronic rhinosinusitis. CF diagnostic testing and pulmonary characteristics were compared between high\u2010risk and low\u2010risk CF groups, and sinus CT findings were compared among all 3 groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When comparing CF cohorts (n = 25 and 30, respectively), earlier age at diagnosis (<jats:italic>p<\/jats:italic> &lt; 0.001), higher sweat chloride values (<jats:italic>p<\/jats:italic> &lt; 0.001), lower forced expiratory volume in 1\u00a0second (FEV<jats:sub>1<\/jats:sub>) values (<jats:italic>p<\/jats:italic> &lt; 0.001), and a higher prevalence of pulmonary infection with <jats:italic>Pseudomonas aeruginosa<\/jats:italic> (<jats:italic>p<\/jats:italic> = 0.001) were found in the high\u2010risk genotype group.\u00a0A significantly increased incidence of sinus hypoplasia\/aplasia and bony sclerosis was seen when comparing both CF groups to the control cohort (n = 30), as well as when comparing the high\u2010risk and low\u2010risk CF genotype cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current study describes clinicopathologic findings of sinus disease in adult CF patients in the context of genotype severity. Our data demonstrate that while patients within a low\u2010risk genotype cohort have generally milder lung disease, they retain classic radiographic findings of CF sinus disease that can help raise the index of suspicion for undiagnosed CF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21412","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T15:21:10Z","timestamp":1410794470000},"page":"915-920","source":"Crossref","is-referenced-by-count":25,"title":["Comparison of radiographic and clinical characteristics of low\u2010risk and high\u2010risk cystic fibrosis genotypes"],"prefix":"10.1002","volume":"4","author":[{"given":"Geoffrey R.","family":"Ferril","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Colorado  Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry A.","family":"Nick","sequence":"additional","affiliation":[{"name":"Department of Medicine National Jewish Health  Denver CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Getz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Colorado  Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry P.","family":"Barham","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Colorado  Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milene T.","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Department of Medicine National Jewish Health  Denver CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Taylor\u2010Cousar","sequence":"additional","affiliation":[{"name":"Department of Medicine National Jewish Health  Denver CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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