{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:56:50Z","timestamp":1778777810889,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T00:00:00Z","timestamp":1411603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010term use of systemic glucocorticoid therapy has been associated with hypothalamic\u2010pituitary\u2010adrenal axis suppression and other systemic adverse events. This pharmacokinetic study evaluated the systemic safety and performance of a bioabsorbable sinus implant that gradually releases 1350\u00a0\u03bcg of mometasone furoate directly to the sinus mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, single\u2010center study treating 5 adult patients with recurrent polyposis after bilateral total ethmoidectomy. Each patient received 2 steroid\u2010releasing implants in\u2010office under local\/topical anesthesia. Plasma concentrations of mometasone furoate and cortisol were determined before placement and through 30\u2010day follow\u2010up, which also included endoscopic grading and patient\u2010reported outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five patients (mean age 46.2 \u00b1 9.2 standard deviation [SD] years; 60% male) underwent successful placement in all 10 ethmoid sinuses. There were no serious adverse events. The plasma concentrations of mometasone furoate were generally below the lower limit of quantification (LLOQ) of the assay (30\u00a0pg\/mL). Cortisol concentrations at follow\u2010up ranged from 3.9 to 5.7\u00a0mg\/dL compared to 4.7\u00a0mg\/dL at baseline. At 1 month, there was a significant improvement in bilateral polyp grade (<jats:italic>p<\/jats:italic> = 0.037), nasal obstruction score (<jats:italic>p<\/jats:italic> = 0.002), and 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022) (<jats:italic>p<\/jats:italic> = 0.010) compared to baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The reported 100% placement success, negligible systemic exposure to mometasone furoate released over time, lack of adrenal suppression, and the absence of serious adverse events suggest that the implant provides a valid and safe option for the in\u2010office treatment of recurrent polyposis. Randomized, controlled, blinded clinical studies are underway to provide further evidence of safety and efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21414","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T14:32:17Z","timestamp":1411655537000},"page":"816-822","source":"Crossref","is-referenced-by-count":24,"title":["Steroid\u2010eluting sinus implant for in\u2010office treatment of recurrent polyposis: a pharmacokinetic study"],"prefix":"10.1002","volume":"4","author":[{"given":"Randall","family":"Ow","sequence":"first","affiliation":[{"name":"Sacramento Ear, Nose and Throat  Roseville CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Groppo","sequence":"additional","affiliation":[{"name":"Sacramento Ear, Nose and Throat  Sacramento CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Clutter","sequence":"additional","affiliation":[{"name":"Sacramento Ear, Nose and Throat  Folsom CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna K.","family":"Gawlicka","sequence":"additional","affiliation":[{"name":"Intersect ENT  Menlo Park CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3950"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.06.726"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3982"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.05.628"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23979"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.12.151"},{"key":"e_1_2_7_8_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","volume":"23","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl."},{"key":"e_1_2_7_9_1","first-page":"1","article-title":"Local and systemic safety of intranasal corticosteroids","volume":"22","author":"Sastre J","year":"2012","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24066"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40136-012-0003-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22228"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21044"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811435968"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20020"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21309"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_7_18_1","volume-title":"Holland\u2010Frei Cancer Medicine","author":"McKay LI","year":"2003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200730040-00004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2008.01.005"}],"updated-by":[{"DOI":"10.1002\/alr.22385","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000}}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21414","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:53:54Z","timestamp":1696622034000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,25]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1002\/alr.21414"],"URL":"https:\/\/doi.org\/10.1002\/alr.21414","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,25]]}}}