{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:35:12Z","timestamp":1780590912810,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T00:00:00Z","timestamp":1410739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The outcomes of endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) can be compromised by postoperative inflammation, recurrent polyposis, middle turbinate lateralization, and synechiae, often requiring subsequent interventions.\u00a0A bioabsorbable steroid\u2010eluting sinus implant placed in the operating room following ESS has been proven safe and effective in 2 randomized controlled trials and a subsequent meta\u2010analysis, for its ability to preserve sinus patency, and reduce medical and surgical interventions. This trial sought to evaluate the safety, feasibility, and outcomes of implants placed in the office after achieving hemostasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty patients with CRS underwent ESS including bilateral ethmoidectomy.\u00a0A steroid\u2010eluting bioabsorbable implant was deployed into each ethmoid cavity in the office within 7 days after ESS. Endoscopic appearance of the ethmoid cavities was evaluated at 1 week, 2 weeks, and 4 weeks postoperatively by the operating surgeon and an independent blinded evaluator. Procedural tolerance was assessed at week 2 using a patient preference questionnaire. The 20\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201020) questionnaire was completed at baseline, week 2, and week 4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In\u2010office placement of steroid\u2010eluting bioabsorbable implants was well tolerated, with 90% of patients very satisfied with the overall experience, and 80% very satisfied with the recovery process. At 1 month, there were no significant adhesions or frank polyposis, and middle turbinate lateralization was only 5%. Compared to baseline, ethmoid sinus inflammation was significantly reduced (<jats:italic>p<\/jats:italic> = 0.03), and the mean SNOT\u201020 score was significantly improved (<jats:italic>p<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In\u2010office placement of steroid\u2010eluting bioabsorbable implants after achieving hemostasis was well tolerated and might improve local drug diffusion and surgical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21416","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T15:22:55Z","timestamp":1410794575000},"page":"808-815","source":"Crossref","is-referenced-by-count":38,"title":["Safety, feasibility, and efficacy of placement of steroid\u2010eluting bioabsorbable sinus implants in the office setting: a prospective case series"],"prefix":"10.1002","volume":"4","author":[{"given":"Keith E.","family":"Matheny","sequence":"first","affiliation":[{"name":"Collin County Ear Nose and Throat  Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Kenny B.","family":"Carter","sequence":"additional","affiliation":[{"name":"Collin County Ear Nose and Throat  Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewen Y.","family":"Tseng","sequence":"additional","affiliation":[{"name":"Collin County Ear Nose and Throat  Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen J.","family":"Fong","sequence":"additional","affiliation":[{"name":"California Sinus Centers  San Francisco CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199901000-00006"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2012","volume":"23","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200003002-00008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2008.12.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3171"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59980300460-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240602000102"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556139207100303"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3418"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31817c0b4d"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3391"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3331"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-002-0534-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20905"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20020"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22228"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811435968"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21044"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.08.044"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.005"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.121022"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181820896"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32835c05e1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941312201101"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01463560"}],"container-title":["International Forum of Allergy &amp; 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