{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:35:33Z","timestamp":1789421733336,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T00:00:00Z","timestamp":1411603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The pathogenesis of human chronic rhinosinusitis with nasal polyps (CRSwNP) comprising eosinophilic CRSwNP (ECRSwNP) and non\u2010eosinophilic (nECRSwNP) is not completely understood. Recent evidence has suggested that platelet\u2010derived growth factor receptor alpha (PDGFR\u03b1) is implicated in cell growth, transformation, proliferation, migration, and vascular permeability and platelet\u2010derived growth factor\u2010A (PDGF\u2010A) is a specific ligand for PDGFR\u03b1. However, little is known about their roles in CRSwNP. Therefore, we aimed to investigate the expression and role of PDGFR\u03b1 and PDGF\u2010A in CRSwNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PDGFR\u03b1 protein expression was investigated by immunohistochemistry method and messenger RNA (mRNA) expression of PDGFR\u03b1 and PDGF\u2010A were assessed by real\u2010time polymerase chain reaction (PCR) in CRSwNP patients and control subjects. Moreover, the effects of various stimulators with different concentrations and time on PDGFR\u03b1 were evaluated on nasal explant culture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Quantitative analysis of immunostaining for PDGFR\u03b1 showed an obvious elevation in immunolabeling of PDGFR\u03b1 in CRSwNP groups compared with controls. Furthermore, PDGFR\u03b1 protein was significantly stronger expressed in ECRSwNP group than nECRSwNP group and atopic patients showed stronger expression of PDGFR\u03b1 protein than nonatopic patients. The mRNA of PDGFR\u03b1 and PDGF\u2010A were overexpressed in CRSwNP, especially in ECRSwNP. PDGFR\u03b1 mRNA expression was closely related to PDGF\u2010A mRNA. In nasal explant culture and stimulation, PDGFR\u03b1 mRNA was augmented by interleukin 4 (IL\u20104), IL\u20105, or IL\u20101\u03b2 respectively, but suppressed by IL\u201027.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PDGFR\u03b1 may play a pivotal role in the pathophysiology of ECRSwNP and nECRSwNP by combining with PDGF\u2010A. IL\u20104, IL\u20105, or IL\u20101\u03b2 may be critical for PDGFR\u03b1 gene expression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21419","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T14:32:59Z","timestamp":1411655579000},"page":"909-914","source":"Crossref","is-referenced-by-count":11,"title":["Role of platelet\u2010derived growth factor\u2010\u03b1 in eosinophilic and non\u2010eosinophilic chronic rhinosinusitis with nasal polyps"],"prefix":"10.1002","volume":"4","author":[{"given":"Hai","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Eye and ENT Hospital of Fudan University  Shanghai China"},{"name":"Department of Otorhinolaryngology Fuzhou General Hospital  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biology and Chemical Engineering Fuqing Branch of Fujian Normal University  Fuqing Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010Sheng","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Pathology Fuzhou General Hospital  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong\u2010Xiong","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Biology and Chemical Engineering Fuqing Branch of Fujian Normal University  Fuqing Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biology and Chemical Engineering Fuqing Branch of Fujian Normal University  Fuqing Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23190"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24305"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1500ED"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01225.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.201005-036RN"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.017"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.10.027"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.50"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino12.000"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/474203"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03198.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21208"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23671"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.07.049"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24154"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346929"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2507"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00001.2013"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2012.4.1.37"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M909785199"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(95)00196-4"}],"container-title":["International Forum of Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Falr.21419","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alr.21419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T01:22:29Z","timestamp":1696555349000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/alr.21419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,25]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1002\/alr.21419"],"URL":"https:\/\/doi.org\/10.1002\/alr.21419","archive":["Portico"],"relation":{},"ISSN":["2042-6976","2042-6984"],"issn-type":[{"value":"2042-6976","type":"print"},{"value":"2042-6984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,25]]}}}