{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:45:24Z","timestamp":1788281124067,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T00:00:00Z","timestamp":1412208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Elevated intracranial pressure (ICP) is an inciting factor for cerebrospinal fluid (CSF) leaks and can be measured by CSF pressure (CSFP) monitoring. Current CSFP literature is limited to the assessments of opening pressure. This study reinvestigates a previously discussed monitoring approach that evaluates continuous CSFP parameters, physiologic measurements, and treatment outcomes in patients undergoing endoscopic repair of spontaneous CSF leaks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of patients undergoing endoscopic endonasal repair of spontaneous CSF leaks. All participants had a lumbar catheter placed for 24\u2010hour continuous preoperative pressure monitoring, and 24 hours of continuous monitoring starting 48 hours after repair. In addition to patient characteristics, mean and peak CSFP, pulse waveform amplitudes (PWAs), and related parameters were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five patients underwent monitoring between 2004 and 2013, with a mean follow\u2010up of 526 days. The mean age was 49.2 years, the mean body mass index (BMI) 38.5, and 8 of 25 (32%) had obstructive sleep apnea. Although mean CSFP and PWA decreased after the repair, mean peak CSFP increased by 1.56 cmH<jats:sub>2<\/jats:sub>O (1.15 mmHg). Six patients (24%) had elevation in their CSFP &gt;25 cmH<jats:sub>2<\/jats:sub>O (18.4 mmHg) for a minimum of 4% of the recording time. Based on their continuous pressure monitoring data, 9 patients (36%) underwent treatment for high ICP, either with acetazolamide or a ventricular shunt. There were no CSF leak recurrences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Continuous perioperative CSFP monitoring provides valuable insight into multiple physiologic parameters. Systematic continuous CSFP monitoring can identify individuals in need of ICP\u2010lowering therapy, possibly improving the outcomes in CSF leak repair surgeries.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21424","type":"journal-article","created":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T12:39:18Z","timestamp":1412253558000},"page":"71-77","source":"Crossref","is-referenced-by-count":22,"title":["Perioperative continuous cerebrospinal fluid pressure monitoring in patients with spontaneous cerebrospinal fluid leaks"],"prefix":"10.1002","volume":"5","author":[{"given":"Yanjun J.","family":"Xie","sequence":"first","affiliation":[{"name":"Johns Hopkins School of Medicine  Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Shargorodsky","sequence":"additional","affiliation":[{"name":"Johns Hopkins Department of Otolaryngology\u2013Head and Neck Surgery  Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Lane","sequence":"additional","affiliation":[{"name":"Johns Hopkins Department of Otolaryngology\u2013Head and Neck Surgery  Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Ishii","sequence":"additional","affiliation":[{"name":"Johns Hopkins Department of Otolaryngology\u2013Head and Neck Surgery  Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Solomon","sequence":"additional","affiliation":[{"name":"Johns Hopkins Department of Neurology  Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay","family":"Moghekar","sequence":"additional","affiliation":[{"name":"Johns Hopkins Department of Neurology  Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary L.","family":"Gallia","sequence":"additional","affiliation":[{"name":"Johns Hopkins Department of Neurosurgery  Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas D.","family":"Reh","sequence":"additional","affiliation":[{"name":"Johns Hopkins Department of Otolaryngology\u2013Head and Neck Surgery  Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.14.2.106"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.27.3.241"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2011.3.JNS101447"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24160"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e318271c312"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2006.08.013"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e318299c292"},{"key":"e_1_2_6_9_1","first-page":"814696","article-title":"Benign intracranial hypertension: a diagnostic dilemma","volume":"2012","author":"Shaw GY","year":"2012","journal-title":"Case Rep Otolaryngol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240301700403"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.12.018"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000209915.16235.6D"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/026990599121872"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1227\/01.NEU.0000108639.16783.39","article-title":"Effects of head posture on cerebral hemodynamics: its influences on intracranial pressure, cerebral perfusion pressure, and cerebral oxygen","volume":"54","author":"Ng I","year":"2004","journal-title":"Neurosurgery"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2010.24.3465"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200007000-00019"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30518-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21262"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.20010"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-012-0257-8"}],"container-title":["International Forum of Allergy &amp; 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