{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T19:07:11Z","timestamp":1782414431171,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T00:00:00Z","timestamp":1411948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Forum Allergy Rhinol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with recurrent sinonasal polyposis after endoscopic sinus surgery (ESS) have limited treatment options. This study evaluated the safety and efficacy of a bioabsorbable steroid\u2010eluting implant with 1350 \u03bcg of mometasone furoate for its ability to dilate obstructed ethmoid sinuses, reduce polyposis, and reestablish sinus patency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized, controlled, blinded study including 100 patients chronic rhinosinusitis with nasal polyposis (CRSwNP) refractory to medical therapy and considered candidates for revision ESS. Follow\u2010up included endoscopic grading by investigators and patient\u2010reported outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treated patients (n = 53; age as mean \u00b1 standard deviation [SD] 47.8 \u00b1 12.6\u00a0years; 55% male) underwent in\u2010office bilateral placement. Control patients (n = 47; age 51.6 \u00b1 13.1\u00a0years; 66% male) underwent a sham procedure. At 3\u00a0months, treated patients experienced a significant reduction in bilateral polyp grade (<jats:italic>p<\/jats:italic> = 0.0269) and ethmoid sinus obstruction (<jats:italic>p<\/jats:italic> = 0.0001) compared to controls. Treated patients also experienced a 2\u2010fold improvement in the mean nasal obstruction\/congestion score (\u22121.33 \u00b1 1.47 vs \u22120.67 \u00b1 1.45; <jats:italic>p<\/jats:italic> = 0.1365). This improvement reached statistical significance (<jats:italic>p<\/jats:italic> = 0.025) in patients with greater polyp burden (grade \u22652 bilaterally; n = 74). At 3\u00a0months, 53% of treated patients compared to only 23% of controls were no longer indicated for repeat ESS. There was no serious adverse event or clinically significant increases in intraocular pressure or cataract formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The symptomatic improvement and statistically significant reduction in polyp grade and ethmoid sinus obstruction supported the efficacy of the steroid\u2010eluting implant for in\u2010office treatment of CRS patient with recurrent polyposis after ESS. The study results demonstrated that the steroid\u2010eluting implant represents a safe and effective alternative to current management for this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/alr.21426","type":"journal-article","created":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T20:45:40Z","timestamp":1412023540000},"page":"861-870","source":"Crossref","is-referenced-by-count":70,"title":["RESOLVE: a randomized, controlled, blinded study of bioabsorbable steroid\u2010eluting sinus implants for in\u2010office treatment of recurrent sinonasal polyposis"],"prefix":"10.1002","volume":"4","author":[{"given":"Joseph K.","family":"Han","sequence":"first","affiliation":[{"name":"Divisions of Rhinology and Endoscopic Sinus\u2010Skull Base Surgery and Allergy Eastern Virginia Medical School  Norfolk VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith D.","family":"Forwith","sequence":"additional","affiliation":[{"name":"Advanced ENT and Allergy  Louisville KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health Sciences University  Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Feinberg School of Medicine Northwestern University  Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Brown","sequence":"additional","affiliation":[{"name":"South Florida ENT Associates, PA  Miami FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K.","family":"Miller","sequence":"additional","affiliation":[{"name":"Intermountain ENT  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall 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